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Somatosensory
Test 2
34
Medical
Graduate
03/06/2012

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Term
Senses
Definition
means by which brain receives info about environment from body
somatic: touch, pressure, temp, prop, pn
visceral: internal organs-pn and pressure
Term
7 Types of Sensory Receptors
Definition
Chemoreceptors: smell and taste
thermoreceptors: temp
photoreceptors: light/vision
nociceptors: pain
exteroreceptors: associated with skin
visceroreceptors: associated with organs
proprioceptors: associated with jts/tendons (GTO)
Term
Sensory Transduction
(ascending pathway)
Definition
adequate stimulus: changes membrane
receptor potential leads to AP
AP produced in receptor or in connected neuron.
Term
Frequency Code of stimulus intensity
Definition
number of AP's per unit of time
Term
Population Code
Definition
more sensory receptors are activated as stimulus intensity increases
Term
Labeled Line code of stimulus quality
Definition
info about quality or type of stimulus is maintained in each pathway without getting mixed with other info
Info sent to thalamus is contralateral
Term
adaptation
Slowly adapting
Rapidly Adapting
Definition
mechanoreceptors vary in persistence of response to long lasting stimulu
slow= merkel's disk and ruffini's endings
rapid= meissners and pacinian corpuscles
Term
Receptive Field
Definition
region of the body surface that causes a sensory nerve cell to respond
Term
Pacinian Corpuscle
Definition
Looks like onion
Fast adapting
large borders
good for rapid changing stimulus, vibration
Term
Meissners corpuscle
Definition
Looks like tornado
good for tactile discrimination, 2 point
Fast adapting
Small sharp borders
Term
Merkel's Disk
Definition
Small Borders
Slow adapting
light touch, superficial pressure
Term
Ruffini's Ending
Definition
Looks like cigar
senses tension
Large Borders
Slow adapting
Term
Free nerve endings
Definition
cold, warm and pain receptors
Term
Primary Afferent Fibers
Definition
Large to small, myelinated to unmyelinated
Aalpha: touch
Abeta: touch
Adelta: pain and Temp
C: Pain and Temp
Term
Primary Afferent Fibers
Definition
Large to small, myelinated to unmyelinated
Aalpha: touch
Abeta: touch
Adelta: pain and Temp
C: Pain and Temp
Term
Second order sensory neurons
Definition
receive input from primary
Myelinated Abeta touch sensitive
Term
Dorsal Column System: Medial Lemniscal
Fasciculus Gracilis
Fasciculus Cuneatus
Definition
Fasciculus Gracilis= below T6
Fasciculus Cuneatus= lateral to gracilis above T6
Term
Dorsal Column- Medial Lemnsicus
Definition
primary neuron enters SC at or below T6 . Ascends to lower medulla and synapses with 2nd neuron in dorsal column nuclei (gracilis/cuneatus). Ascend then Cross
Term
Medial Lemniscus sensations
Definition
2 point discriminiation, proprioception, pressure, vibration
Term
Trigeminal Touch - Trigeminal Nerve (5)
Definition
somatic sensation of face
breaks into 2 nerves to innervate face, mouth, tongue (opthalmic, maxillary, mandibular)
Term
Somatosensory Cortex
Definition
S1=Area 3b (touch)receives info from thalamus
postcentral gyrus
3a (proprioception)
1&2 receive info from 3b- texture, size and shape
Term
Homunculus
Definition
legs and trunk fold over the midline; the arms and hands are along the middle
face is near the bottom
the lips and hands are enlarged since a larger number of neurons in the cerebral cortex are devoted to processing information from these areas.
Term
Posterior Parietal Cortex Damage
Definition
needs info from visual system, the auditory system, and the somatosensory system

Agnosia: inability to recognize objects
Neglect Syndrome: part of the body or world is ignored
Term
Pain vs Nociception
Definition
Pain= feeling of sore, aching, throbbing
nociceptoin= sensory process, provides signals that trigger pain
Term
Transduction of Pain
Definition
Mechanically gate channels opened by strong mech stimulation, temp extremes, oxygen deprivation, chemicals
Damaged cells release substance to open ion channels
-proteases (bradykinin), ATP, K
- Mast cells: histamine released causes depolarization (GPCR)
-Lactic Acid: H activates H gated channels
Term
Type of Nociceptors

Hyperalgesia
Definition
Polymodal: chemical, thermal, mechanical
Mechanical
Thermal
Chemical
Hyperalgesia: Primary- directly in damaged tissues
secondary: in surrounding undamaged tissues
Term
Fast vs Slow Pain

Aspirin?
Definition
first pain= Adelta, sharp
second pain= C, dull pain

Aspirin works on slow pain because it crosses into unmyelinated fibers
Term
Referred Pain
Definition
ex) Angina
Dorsal Nerve Nuclei run in same cells and body misinterprets origin
Term
zone of lissauer (posterolateral tract)
Definition
1st order neurons carry discriminative pain and temperature information (location, intensity and quality
terminate in substantia gelatinosa
Term
Differences between touch and pain pathways
Definition
1) Nerve endings: touch= specialized structures, pain= free nerve endings
2) diameter of axon- touch= fast Abeta, pain= slow Adelta and C
3) Spinal cord connections: touch= ipsilateral pain= contralateral
Abeta terminate in deep dorsal horn
Adelta &C terminate in substantia gelatinosa
Term
Spinothalamimc Pathway
Definition
Cross then ascend
Adelta, C= pain
Term
Raphe Nuclei
Definition
Release serotonin into brain
inhibit pain sensation
Term
Spinocerebellar System
posterior vs anterior
Definition
carry proprioceptive info to cerebellum
posterior= ipsilateral (inferior cerebellar peduncle)
anterior= contralateral (crosses 2x)(superior cerebellar peduncle)
Term
Cold and Hot Receptors
Definition
Cold= A delta and C
5-10x more abundant
temps less than 30 C
Hot= C
temps more than 30 C
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