Term
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Definition
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Term
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Definition
| Highly potent synthetic glucocorticoid that suppresses acute and chronic inflammmation; potentiates vascular smooth muscle relaxation by beta-adrenergic agonists. |
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Term
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Definition
| Acute spinal cord trauma, anaphylaxis, broncodilator for unresponsive asthma |
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Term
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Definition
| Premature infants, systemic fungal infections, use with caution in patients with gastrointestinal bleeding. |
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Term
| Adverse reactions/side effects |
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Definition
| Depression, euphoria, headache, restlessness, seizure, increased ICP, pulmonary tuberculosis, hypertension, CHF, nausea, vomiting, peptic ulcer, fluid retention, hypernatremia, hyperkalemia. |
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Term
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Definition
| Hypoglycemic responses to insulin and hypoglycemic agents may be blunted. |
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Term
Dosage and administration
Adult |
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Definition
| Acute spinal cord trauma; 30 mg/kg IV over 30 minutes followed by: Infusion: 5.4 mg/kg/h. Asthma, COPD, anaphylaxis: 1-2 mg/kg IV. |
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Term
Dosage and administration
Pediatrics |
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Definition
| Acute spinal cord trauma: Same as adult. Status asthmaticus/anaphylaxis: 2 mg/kg/dose IV/IO/IM to a maximum dose of 60 mg. |
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Term
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Definition
Onset: 1-5 minutes
Peak effect: variable
Duration: 6-8 hours. |
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Term
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Definition
| Pregnancy Safety: Category C. Not effective if time of spinal cord injury greater than 8 hours. Crosses the placenta and may cause fetal harm. |
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