Term
| Definition of juvenile aggressive fibromatosis |
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Definition
| Group of fibrous proliferation w/ properties ranging from benign to malignant neoplasms |
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Term
| Etiology of JAF (juvenile aggressive fibromatosis) |
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Definition
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Term
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Definition
| Rare, children, young adults, gingiva in mandible, destructive; facial disfigurement; nothing that screams fibromatosis need to biopsy |
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Term
| Clinical significance of JAF |
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Definition
| Example of neoplasm of fibroblastic cells, disfiguring, high recurrence rate, increased incidence in pts with FAP & Gardner syndrome; do not confuse w/ hereditary gingival fibromatosis |
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Term
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Definition
| Interlacing proliferation of spindle shaped cells w/ fibroblastic features arranged in streaming fascicles |
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Term
| Definition of fibrosarcoma |
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Definition
| Malignancy of fibroblasts that would normally make collagen and all of your ground substance |
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Term
| Is Fibrosarcoma common or uncommon? |
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Definition
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Term
| What you see histologically with fibrosarcoma and how to treat |
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Definition
| Very cellular proliferation of spindle-shaped cells that are fibroblast derived. Treat aggressively with surgical excision |
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Term
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Definition
| Benign proliferation of adipocytes |
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Term
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Definition
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Term
| Clinical features of lipoma |
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Definition
| Uncommon in oral cavity, more prevalent in obese?, superficial ones = yellow, deeper ones = nonspecific pink; esp BM, buccal vestibule |
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Term
| Clinical significance of lipoma |
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Definition
| example of benign neoplasm of adipocytes, low recurrence rate |
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Term
| Definition of liposarcoma |
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Definition
| Malignant neoplasm of fatty origin/adipocytes |
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Term
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Definition
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Term
| Clinical features of liposarcoma |
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Definition
| very rare in head and neck area |
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Term
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Definition
| Treat fairly aggressively, radical excision; high recurrence rate |
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Term
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Definition
| Lipoblast (type of fat cell that has very large plump nuclei not usually seen in benign fat) |
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Term
| Liposarcoma clinical significance |
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Definition
| Example of malignant neoplasm of adipocytes |
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Term
| Traumatic neuroma definition |
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Definition
| PAINFUL nodular proliferation of nerve and fibrous tissue of nerve sheath resulting from futile attempt of sectioned nerve fibers to reunite |
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Term
| Pathology of traumatic neuroma |
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Definition
| When nerves get separated, they try to connect together again but sometimes it doesn't work; get attempt of repair and get a lot of excess nerve tissue made and CT in betwee --> painful |
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Term
| Etiology of traumatic neuroma |
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Definition
| Reactive, after sectioning of nerve; somewhat uncommon |
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Term
| Histology of traumatic neuroma |
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Definition
| small haphazard nerve bundles in tissue; dense CT |
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Term
| Definition of neurilemoma/Schwannoma |
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Definition
| well-demarcated benign neoplastic proliferation of Schwann cells (cover your axon) |
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Term
| Another name for Neurilemoma/Schwannoma |
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Definition
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Term
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Definition
| Uncommon, esp tongue; floor of mouth (places where we have a lot of nerves), can occur in bone may lead to numbness |
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Term
| Significance of neurilemoma |
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Definition
Example of benign neoplasm of tissue supporting nerve
If bilateral neoplasms of "vestibular nerve" = "acoustic neuromas" consider NF2 |
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Term
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Definition
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Term
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Definition
| Area of tumor under microscope where you can see all of the nuclei lined up, look like they are forming in collections --> cellular area; verocay bodies |
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Term
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Definition
| area between nuclei that are lined up, acellular |
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Term
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Definition
| Where they more haphazard, loose stuff, more stuff mixed in |
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Term
| Definition of neurofibroma |
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Definition
| benign neoplasm of both Schwann cells and perineural fibroblasts |
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Term
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Definition
| Submucosal soft tissue mass, occur anywhere, young adults; skin > oral cavity, in oral cavity: tongue BM |
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Term
| Significance of Neurofibroma |
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Definition
Example of benign neoplasm of nerve AND supporting tissue
Possible relationship to NF1? |
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Term
| Melanotic neuroectodermal tumor of infancy definition |
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Definition
| Rare pigmented neoplasm that occurs during 1st year of life |
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Term
| Etiology of melanotic neuroectodermal tumor of infancy |
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Definition
| Neoplasm: benign to intermediate |
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Term
| Clinical features of melanotic neuroectodermal tumor of infancy |
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Definition
| Black!!, anterior maxilla!, soft tiss mass+bone destruction, increased serum levels of catecholamines (VMA - Vanillylmandellic acid) |
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Term
| Increased serum levels of catecholamines (VMA-Vanillylmandelic acid) is associated with which type of tumor? |
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Definition
| Melanotic neuroectodermal tumor of infancy |
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Term
| Histology of melanotic neuroectodermal tumor of infancy |
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Definition
| One of cells is melanocytic - makes pigment, other type of cell is neuroectodermal origin - can produce catecholamines |
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Term
| Malignant peripheral nerve sheath tumor |
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Definition
| Most common malignancy of peripheral nerves |
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Term
| Etiology of malignant peripheral nerve sheath tumor |
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Definition
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Term
| Clinical malignant peripheral nerve sheath tumor |
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Definition
| Rare, 50% of cases in pts w/ NF1; pts with NF1 have 1-2% of risk of developing nerve tumors |
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Term
| Prognosis of malignant peripheral nerve sheath tumor |
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Definition
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Term
| Neurofibromatosis (NF1) other names |
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Definition
| Von Recklinghausen's disease of skin |
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Term
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Definition
| NF1 gene mutation, 1:3,000; 50% inherited other half are spontenous; 50% new mutations |
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Term
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Definition
| Multiple neurofibromas (anywhere on skin, oral cavity); risk of malignant transformations to MPNST |
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Term
| Diagnostic criteria for NF1 |
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Definition
| 2 or more of the following: 6 or more cafe-au-lait macules (>5 mm prepubertal) or >15 mm (postpubertal); 2 or more neurofibroma or 1 plexiform neurofibroma; freckling in axillary or inguinal region; optic glioma benign tumors of optic nerve; 2 or more Lisch nodules (localized collections of melanocytes around iris hamartomas); distinctive osseous lesion; 1st degree relative w/ NF1 |
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Term
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Definition
Oral neurofibromas in 72-92%
Other oral lesions:
Enlargement of fungiform papillae (tongue)
Enlargement of mandibular canal |
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Term
| Multiple endocrine neoplasia 2B (MEN II) |
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Definition
Because of pheochromacytoma also have excess catecholamine secreted- diuretic, diarrhea, headache, etc
If pt left laone will lead to medullary carcinoma so need to take out thyroid gland and provide supplementation
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