Term
| T/F Soft Tissue tumor - lower grade is better. |
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Definition
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Term
| What do soft tissue tumors metastasize thru? |
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Definition
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Term
| What is the translocation w/ Ewing's Sarcoma? |
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Definition
|
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Term
| What is the translocation w/ Synovial Sarcoma? |
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Definition
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Term
| What are fibrous and fibrohistiocytic tumors associated with? |
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Definition
| Trauma. Usually regress spontaneouly. Benighn. |
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Term
| What is the most common soft tissue tumor? |
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Definition
| Lipoma - benign - cured by resection. |
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Term
| What is the prognosis for liposarcoma related to? |
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Definition
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|
Term
| What is the most common soft tissue tumor in kids? |
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Definition
| Rhabdomyosarcoma. Malignant tumor of skeletal muscle. |
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|
Term
| What is a malignant tumor of smooth muscle? |
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Definition
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|
Term
| What is neurofibromatosis? |
|
Definition
| Aut. dominant - skin lesions. |
|
|
Term
| What chromosome is Neurofibromatosis type 1 associated with? |
|
Definition
| 17 -also called von recklinhausen. |
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|
Term
| What is associated with NF1? |
|
Definition
| MPNSTs. Malignant Peripheral Nerve Sheath Tumor.. |
|
|
Term
| What chromosome is Neurofibromatosis type 2 associated with? |
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Definition
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|
Term
| What is a characteristic lesion of NF2? |
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Definition
| Acoustic Shwannomas. Tumor of the myelin producers of CN VIII. |
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|
Term
| What causes synovial sarcoma? |
|
Definition
| Idiopathic. Can arise in joint or elsewhere. Typically a high grade. |
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|
Term
| What induces osteoclastic activity? |
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Definition
|
|
Term
| What is the first stage of healing after a bone fracture? |
|
Definition
| Hematoma - extravasation of blood outside the vessels. |
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|
Term
| What is the second stage of healing after a bone fracture? |
|
Definition
| Callue formation - deposition of bone & cartilage matrix within hematoma. Happens 1-3 weeks after fracture. |
|
|
Term
| What is the third stage of healing after a bone fracture? |
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Definition
| Callus remodeling - blasts and clasts work together to form strong bone architecture. |
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|
Term
| How is osteomyelitis transmitted? |
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Definition
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Term
|
Definition
| Acute or chronic bone infection. |
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|
Term
| What is the most common pathogen in osteomyelitis? |
|
Definition
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|
Term
| What hormonal deficiency is related to Osteoporosis? |
|
Definition
|
|
Term
| What are the histological characteristics of Osteoporosis? |
|
Definition
| Less bone w/ cortical bone and bony trabeculae. |
|
|
Term
| What is Vit. D deficiency called? |
|
Definition
| Rickets and Osteomalacia. |
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|
Term
|
Definition
|
|
Term
| What is the late form of Paget's disease called? |
|
Definition
|
|
Term
|
Definition
| Late thickening of bone due to net osteoblastic activity. |
|
|
Term
| How is neoplastic bone disease diagnosed? |
|
Definition
| Radiology, histology, patient characteristics, location, can't just look at histology. |
|
|
Term
| T/F Gardener's Syndrome is benign. |
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Definition
|
|
Term
| What is characteristic in Gardener's Syndrome? |
|
Definition
| Presence of polyps in the colon and tumors outside the colon. Osteomas. |
|
|
Term
| Who is affected in Giant cell tumors? |
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Definition
|
|
Term
| Where do giant cell tumors occur? |
|
Definition
|
|
Term
| Giant cell tumor - giant multinucleated cells mixed with small uninucleate cells - which is neoplastic? |
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Definition
|
|
Term
| What is characteristic for osteosarcoma? |
|
Definition
| Osteoid - bone matrix - affects young people = metaphyses of appendiceal beones. |
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|
Term
| Osteosarcoma/Chondrosarcoma - which affects young people/old people? |
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Definition
|
|
Term
| What does osteoarthritis affect? |
|
Definition
| Large joints - trauma and congenital abnormalities are primary influences. |
|
|
Term
| When is osteoarthritis worst? |
|
Definition
| After use - late in the day. |
|
|
Term
|
Definition
| Autoimmune - lymphocyte and immune comples. RF - serum marker for the disease. |
|
|
Term
| T/F RA is bilaterally symmetric? |
|
Definition
|
|
Term
| What joints does RA infect? |
|
Definition
| Small joints initially - progresses to large joints. |
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|
Term
|
Definition
| In the morning - after inactivity.. |
|
|
Term
| What causes cartilage destruction w/ inflammation and pannus form/granulation tissue? |
|
Definition
|
|
Term
| What is present in synovial fluid with IA? |
|
Definition
| Infectious Arthritis - Neutrohpils - no crystals. These are present in GA. |
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|
Term
| What is the pathogenesis of Gouty Arth? |
|
Definition
| Hyperuricemia (urea in blood) leads to deposits in joints. |
|
|
Term
| What is the classic site for GA? |
|
Definition
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