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Skeletal System Pathology
Pathologic conditions of the skeletal system
149
Pathology
Undergraduate 4
09/02/2013

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Term
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Definition
Acromegaly
Term
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Definition
Spondylolithesis
Term
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Definition
Osteoarthritis of the knee
Term
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Definition
Osteogenesis Imperfecta
Term
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Definition
Osteomalacia
Term
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Definition
Psoriatic Arthritis
Term
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Definition
Paget's Disease of skull
Term
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Definition
Reiter's Syndrome
Term
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Definition
Rheumatoid Arthritis
Term
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Definition
Rheumatoid Arthritis
Term
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Definition
Rickets - Bowing
Term
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Definition
Scoliosis
Term
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Definition
Simple Bone Cyst
Term
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Definition
Spina Bifida Occulta
Term
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Definition
Osteochondroma
Term
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Definition
Osteoarthritis - Hip
Term
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Definition
Osteoporosis - picture frame
Term
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Definition

Acromegaly -

scalloping with enlarged bodies

Term
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Definition
Bilateral Cervical Ribs
Term
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Definition
Blowout Metastases
Term
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Definition
Congenital Dislocation of hips
Term
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Definition
Gout
Term
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Definition
Gout - rat bites
Term
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Definition
Herniated disc
Term
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Definition
Hydrocephalus
Term
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Definition
Meningomyelocele
Term
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Definition
Multiple Myeloma
Term
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Definition
Multiple Myeloma
Term
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Definition
Osteopetrosis
Term
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Definition
Osteogenic Sarcoma
Term
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Definition
Paget's Disease
Term
Diaphysis
Definition
Main shaftlike portion; primary center of ossification
Term
Epiphyses
Definition
ends of the bone; secondary center of ossification
Term
Epiphyseal Line
Definition
cartilage between the diaphysis and epiphyses; growth plate
Term
Salter-Harris Fracture
Definition
fracture of the growth plate
Term
Metaphysis
Definition
Newly formed bone at the end of diaphysis where the diaphysis and epiphyses fuse together
Term
Compact Bone
Definition
outer layer of bone
Term
Haversian Systems
Definition
the matrix of compact bone
Term
Cancellous Bone
Definition
spongy bone composed of marrow filled spaces separated by trabeculae
Term
Lamellae
Definition
concentric circles of compact bone
Term
Functions of Bones
Definition
1. Support system
2. Protect vital organs
3. Serve as levers for muscles
4. Production of RBCs in the red marrow
5. Storehouse for calcium
Term
Axial skeleton
Definition
skull, sternum & ribs
Term
Appendicular skeleton
Definition
appendiges
Term
fibrous joint
Definition
contains dense connective tissue; no movement (skull bones)
Term
cartilaginous joint
Definition
dense connective tissue and cartilage; slight movement (intervertebral, symphasis pubis, dital tibfib joint)
Term
synarthrodial joint
Definition
fibrous, no movement (skull sutures, ribs with sternum)
Term
amphiarthrodial
Definition
cartilaginous, some movement (dital tibfib joint)
Term
diarthrodial
Definition
synovial, freely moving (elbow, hip)
Term
Osteogenesis Imperfecta
Definition
-"brittle bones"
-Inherited disorder of connective tissue
-Causes bizarre deformities
-wormian bones
-mimics child abuse
-flattened vertebral bodies
-use lesser kV
Term
"brittle bones"
Definition
Osteogenesis Imperfecta
Term
Achondroplasia
Definition
-most common form of dwarfism
-results from reduction in the reproduction of cartilage cells in the growth plates
-short limbs, large head, saddle nose
-increase kV
Term
most common form of dwarfism
Definition
Achondroplasia
Term
Results from the reduction in the reproduction of cartilage cells in the growth plate
Definition
Achondroplasia
Term
Characterized by short limbs, large head, saddle nose and juttin jaw
Definition
Achondroplasia
Term
Acromegaly
Definition
-endocrine disorder
-increased secretion of GH
-characterized by: thick and coarse bones, enlarged sella turcica, skull changes, prominent forehead and jutting jaw, widened teeth, abnormally large hands, coarse facial features
Term
An endocrine disorder that results in over secretion of growth hormone
Definition
acromegaly
Term
Hyperthyroidism
Definition
-results from excessive production of thyroid hormone
-calcium is dumped in the blood, from the bones
-leads to bone destruction and renal calculi
-decreased bone density in phalanges and clavicles
-aka osteoitis fibrosa cystica
Term
also known as osteoitis fibrosa cystica
Definition
Hyperthyoidism
Term
Results from excessive production of thyroid hormone
Definition
Hyperthyroidism
Term
Causes bones to dump calcium into the blood to be absorbed in the GI and kidneys
Definition
Hyperthyroidism
Term
Ischemic Necrosis
Definition
- caused by loss of blood supply to bone
- femoral head is the most common site
Term
Caused by the loss of blood supply to bone
Definition
Ischmic Necrosis
Term
Multiple Myeloma
Definition
-widened malignancy of plasma cells
-associated with bone destruction, bone marrow failure and recurrent infections
-attacks intramedullary canal of the diaphysis
-multiple punched out osteolytic lesions scattered throughout skeletal system
-flat bones containing red marrow are primarily affected
Term
Causes multiple punched out oseteolytic lesions scattered throughout the skeletal system
Definition
Multiple Myeloma
Term
Associated with bone destruction, bone marrow failure and recurrent infections
Definition
Multiple Myelome
Term
Bone Metastases
Definition
-most common malignant bone tumors
-spread via the bloodstream or lymphatic vessels
-blow outs
Term
Most common malignant bone tumors
Definition
Bone Metastases
Term
Blow Out Metastases
Definition
single large metastatic focus that may appear as an expansive trabeculated lesion
Term
Chondrosarcoma
Definition
-malignant tumor of cartilaginous origin
-may stem from an ostepchondroma or endochondroma
-commonly occur in long bones but often originate in a rib, scapula or vertebra
Term
Malignant tumor of cartilaginous origin
Definition
Chondrosarcoma
Term
Ewing's Sarcoma
Definition
-malignant tumor arising in the bone marrow of long bones
-ill defined permeative area of bone destruction that involves a large central portion of the shaft of a long bone
Term
Malignant tumor arising inthe bone marrow of long bones
Definition
Ewing's Sarcoma
Term
Osteogenic Sarcoma
Definition
-generally occurs in the end of a long bone in the metaphysis
-sunburst pattern
-Codman's triangle
Term
Takes on a sunburst pattern
Definition
Osteogenic sarcoma
Term
Codman's triangle
Definition
thin periosteal elevation and subsequent new bone formation at periphery of the neoplastic lesion
Term
Osteoid Osteomas
Definition
-most common in femur and tibia
-oroginate in osteoblastic cells
-less than 1.5cm in diameter
-has a double density
-has a lucent center (nidus)
Term
Simple Bone Cyst
Definition
-true, fluid filled cyst with a wall of fibrous tissue
-not a true neoplasm, but can resemble one
-appears as a lucent lesion with an oval configuration with its long axis parallel to the host bone
Term
A true, fluid filled cyst with a wall of fibrous tissue
Definition
Simple Bone Cyst
Term
Bone Island
Definition
-over deposit of calcium
-common in pelvis and upper femora
-appear in every bone except the skull
Term
An over deposit of calcium common in the pelvis and upper femora
Definition
Bone Island
Term
Endochondroma
Definition
-benign cartilaginous tumor arising from medullary cavity
-found in children and young adults
-involve primarily small bones of hands and feet
-expands bone locally and often leads to pathologic fractures
Term
Benign cartilaginous tumor arising from the medullary cavity
Definition
Endochondroma
Term
Giant Cell Tumors
Definition
-osteoclastomas
-Benign tumor that typically arises at the end of the distal femur or proximal ibia after epiphyseal closure
-produces characteristic appearance of multiple large bubble separated by thin strips of bone
Term
osteoclastomas
Definition
Giant Cell Tumors
Term
osteoma
Definition
-most often arise in outer table of skulls and mandible
-appear as well circumscribed, extremely dense, round lesions
-rarely more than 2cm diameter
Term
osteopetrosis
Definition
-"marble bones"
-increased bone density but bone marrow does not form and bones become brittle
-can be fatal in utero
-symmetric, generalized increase in bone density
-increase exposure factors to compensate for increase in bone formation
Term
"marble bones"
Definition
osteopetrosis
Term
scoliosis
Definition
-twisting and curvature of spine laterally
Term
Spina Bifida
Definition
-posterior defect of spinal canal resulting in split in vertebral arch
-slight dimpling or tuft of hair indicates the site
-meningocele
-meningomyelocele
-chiari II malformation leads to hydrocephalus
Term
meningocele
Definition
herniation of meninges
Term
myelomeningocele
Definition
herniation of meninges and portion of spinal cord or nerve roots
Term
Infection Arthritis
Definition
-pyogenic organisms gain entry into joint
-most commonly caused by Lyme disease
-soft tissue swelling
-joint space narrowing caused by rapid destruction of articular cartilage
-joint ankylosis
Term
Tuberculous Osteomylitis
Definition
-involves the hip, knee and spine
-Pott's disease=tuberculosis of the spine
-causes narrowing of intervertebral discs
-progressive vertebral collapse and anterior wedging with kyphosis
-lytic lesion without periosteal elevation
Term
Pott's diease
Definition
tuberculosis of the spine
Term
Osteomylitis
Definition
-inflammation of the bone and bone marrow caused by infection in the blood stream
-not evident radiographically until day 10
-metaphyseal lucency
-peristeum elevates and a involvrum is formed
-CT & MRI are best ways to diagnose
Term
Akylosing spondylitis
Definition
-variant of RA
-begins in the SI joints
-involves the spine; progressive from the lumbar spine upwards
-destroys articular cartilage
-bamboo spine
-limitation of activity leads to generalized skeletal osteoporosis and fractures
Term
bamboo spine
Definition
Akylosing spondylitis
Term
Reiter's Syndrome
Definition
-veriant of RA
-primarily affects young adult men
-characterized by arthritis, urethritis and conjunctivitis
-involes SI joints, heel and toes
-asymmetric
-erosive
Term
Rheumatoid arthritis
Definition
-chronic systemic disease
-unknown cause
-imflammatory arthritis of small joints of hands and feet
-mainly IPs
-uniform/symmetric narrowing of joints
-fibrous scarring causes ankylosis
-commonly causes ulnar deviation of the hands
-in cervical spine, produces atlantoaxial sublaxation (partial dislocation)
Term
Bursitis
Definition
-inflammation of the bursa
-radiographic sign=calcium in adjacent tendons
-decrease kV to better demonstrate Ca deposits
Term
Osteoarthritis
Definition
-characterized by loss of joint cartilage and reactive new bone formation
-caused by "wear & tear" of aging
-predominantly affects weight bearing joints
-narrowing of joint spaces is irregular
-development of osteophytes
-Heberden's nodes
Term
Psoriatic arthritis
Definition
-variant of RA
-destruction of DIPs by erosion
-produces asymmetric destruction
-causes little or no periarticular osteoporosis
Term
Rotator cuff tear
Definition
rotator cuff = teres minor, infraspinatus and subscapularis muscles
-demonstrated thru arthography
Term
Menisci tear
Definition
-caused by wear and tear
-MRI is modality of choice
Term
Osteporosis
Definition
-generalized or localized deficiancy of bone matrix
-caused by accelerated reabsorption of bone related to aging and postmenopausal hormonal changes
-cortical thinning producing a "picture frame" pattern
Term
Osteomalacia
Definition
-insufficient mineralization of adult skeleton attributed to inadequate intake of calcium, phosphorus and vit D
-"bone softening"
-possible causes: kidney disorder, malabsorption synfrome and inability to absorb vit D
-bones look spongelike and cortical borders of spine are fuzzy
-can cause bowing deformaties
Term
Bones look spongelike and cortical borders are fuzzy
Definition
Osteomalacia
Term
Gout
Definition
-increased acid in blood leads to deposition of uric acid crystals in joints, cartilage and kidneys
-extremely painful arthritis that initially attacks a single joint, usually 1st MTP joint
-tophi=clumps of urate crystals that erode underlying bone
-"rat bites"
Term
"rat bites"
Definition
gout
Term
increased uric acid in blood leads to deposition of uric acid crystals in joints, cartilage and kidneys
Definition
gout
Term
Rickets
Definition
-osteomalcia in children
-caused by deficiancy of vit D in diet or lack of exposure to UV radiation
-best visualized at sternal ends of ribs, proximal ends of tibia & humerus and dital ends of radius & ulna
-cupping of metaphyseal ends of bone
-metaphyseal lines disappear
-"rickety rosary"
-pigeon breast
Term
osteomalacia in children
Definition
rickets
Term
fibrous dysplasia
Definition
-proliferation of fibrous tissue within the medullary cavity
-loss of trabecular markings and widening of bone
-primarily in long bones
-ground-glass density
Term
Gives bones a "ground-glass" density
Definition
fibroud dysplasia
Term
proliferation of fibrous tissue within the medullary cavity
Definition
fibrous dysplasia
Term
Paget's Disease
Definition
-aka osteitis deformans
-destruction of bone followed by a reparative process
-weakened, deformed and thickened boney structures that fracture easily
-results in a mottled, cotton-wool appearance
-blade of grass appearance in long bones
-possible compression of brainstem
Term
osteitis deformans
Definition
Paget's Disease
Term
Results in a mottles, cotton-wool appearance
Definition
Paget's Disease
Term
"blade of grass" appearance in long bones
Definition
Paget's Disease
Term
Lead Poisoning
Definition
-results in the injestion of lead containing materials or occupational inhalation of lead fumes
-high concentrations of lead are deposited in the most rapidly growing portions of the skeleton
-lead lines across metaphyses of long bones and margins of flat bones
Term
Osteochondroma
Definition
-benign projection of bone with a cartilaginous cap
-arises in childhood and teen years
-grows laterally from epiphysis
Term
Grows laterally from epiphysis
Definition
Ostechondroma
Term
Herniated Disc Pulposus
Definition
-intervertebral disc narrowing
-bony sclerosis
-vacuum phenomenon
Term
Degenerative Disc Disease
Definition
-slipped disc
-caused by injury or age
Term
Spondylolithesis
Definition
-displacement of one vertebrae over another
Term
displacement of one vertebrae over another
Definition
Spondylithothesis
Term
Spondylolysis
Definition
-broken pars interarticularis (neck of scottie dog)
-no displacement of vertebrae
Term
Broken pars interarticularis with no displacement of vertbrae
Definition
Spondylolysis
Term
cotton-wool appearance
Definition
Paget's disease
Term
a cleft in the pars interarticularis between the superior and inferior articular processes in the vertbra
Definition
Spondylolysis
Term
A deposit of uric acid in the joint
Definition
gout
Term
a malignant tumor of cartilaginous origin that may originate anew or within a preexsisting cartilaginous lesion
Definition
Chondrosarcomna
Term
abnormal decrease in bone density due to lack of calcium deposits
Definition
osteoporosis
Term
arises in the bone marrow of long bones and affects younf adults
Definition
Ewing's sarcoma
Term
benign bone projection with a cartilaginous cap
Definition
osteochondroma
Term
brittle bone disease
Definition
osteogenesis imperfecta
Term
caused by vitamin deficiency in children
Definition
Rickets
Term
classic "sunburts" pattern with elevated periosteum
Definition
Osteogenic sarcoma
Term
Concentraion deposited in the rapidly growing portions of bones, especially the metaphyses
Definition
Lead poisoning
Term
degenerative arthritis
Definition
osteoarthritis
Term
failure of cartilage to form properly, resulting in dwarfism
Definition
achondroplasia
Term
infection of the bone and its marrow
Definition
osteomyelitis
Term
inflammation of the fluid-filled sac usually dut to repeated physical activity
Definition
burisitis
Term
lack of neural tube closure
Definition
spina bifida
Term
marble bone disease
Definition
osteopetrosis
Term
most commonly affects the thoracic and lumbar spaine with poorly marginated bone destruction often associated with an abcess
Definition
Pott's disease
Term
proliferation of fibrous tissue in the medullary cavity
Definition
fibrous dysplasia
Term
rupture of central nucleus pulposus, most frequently L4-L5
Definition
herniated intervertebral disk
Term
true fluid-filled area surrounded by a fibrous wall
Definition
unicameral bone cyst
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