Term
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Definition
| Ras pathway. Binds to tyrosine receptor kinases. (FGF) |
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Term
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Definition
| Binds FGF. Phosphorylation of the receptor tail leads to activation of Ras (exchanges GDP for GTP) (FGF) |
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Term
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Definition
| Activated by phosphorylation of tyrosine receptor kinase tail. Exchanges GDP for GTP. Eventually leads to activation of MAP-K pathway. (FGF) |
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Term
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Definition
| Terminal protein of this pathway can enter nucleus and serve as a transcription factor. (FGF) |
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Term
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Definition
| Protein that binds to frizzled, a multi-pass transmembrane protein. (Wnt) |
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Term
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Definition
| Multi-pass transmembrane protein. Binds Wnt. When active, activates disheveled. (Wnt) |
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Term
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Definition
| Cell membrane protein. Activated due to activation of frizzled. When activated, deactivates GSK-3. (Wnt) |
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Term
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Definition
| When active, targets beta-catenin for destruction by the proteasome. Deactivated when disheveled is active. (Wnt) |
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Term
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Definition
| Can enter nucleus and bind to LEF/TCF, and this complex can act as transcription factors (for c-myc for example, an oncogene). Beta-catenin is marked for destruction when GSK-3 is active. (Wnt) |
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Term
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Definition
| When bound to beta-catenin, can act as a transcription factor (Wnt). |
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Term
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Definition
| Binds to and activates patched. (SHH) |
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Term
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Definition
| Activated by binding of SHH. Interacts closely with smoothened. Normally, patched inhibits smoothened. When activated, patched no longer inhibits smoothened. (SHH) |
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Term
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Definition
| Interacts with patched. Normally inactive due to patched inhibition. When Patched is active, no longer inhibits smoothened. When smoothened is active, inhibits PKA and Slimb from cleaving Ci. When smoothened is inactive, PKA and Slimb cleave Ci. (SHH) |
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Term
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Definition
| Along with Slimb, regulates cleavage of Ci. With Smoothened inactive, PKA and Slimb cleave Ci. With Smoothened active, PKA and Slimb are inhibited and Ci is not cleaved (SHH) |
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Term
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Definition
| Along with PKA, regulates cleavage of Ci. With Smoothened inactive, PKA and Slimb cleave Ci. With Smoothened active, PKA and Slimb are inhibited and Ci is not cleaved (SHH) |
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Term
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Definition
| Transcription factor. When PKA/Slimb activated, Ci is cleaved and acts as a repressor for certain genes. With PKA/Slimb inhibited, Ci is not cleaved and acts as an activator for gene transcription. (SHH) |
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