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SGU Immuno Post MT: Treatments
SGU Immuno Post MT: Treatments
64
Immunology
Professional
01/12/2013

Additional Immunology Flashcards

 


 

Cards

Term
How does Rickettsia Rickettsii evade immune system ?
Definition
Escapes to the phagocytic cytosol
Term
How does Shigella evade immune system ?
Definition
Toxin destroys endothelial cells and macrophages
Term
How does Streptococcus Pneumoniae evade immune system ?
Definition
Uses a polysaccharide capsule
Term
How does Mycobacterium Tuberculosis evade immune system ?
Definition
Inhibits fusion of phagosome and endosome with lysosomes
Term
How does Borrelia Burgdorferi evade immune system ?
Definition
VIsE (varible major protein like sequence) expressed
Term
CCR5 antagonists block HIV infection how ?
Definition
Block binding of gp 120 protein
Term
What cytokines enhance macrophage cytotoxicity ?
Definition
TNF and IFNgamma
Term
What is CD25 ?
Definition
IL-2 receptor
Used as a marker to identify CD4+ FoxP3 Treg cells.
Expressed in some B cell neoplasms and TILS
Term
Tregs is a good therapy for what diseases ?
Definition
A C O
Autoimmune disease
Cancer
Organ transplantation
Term
Tregs is a bad therapy for what diseases ?
Definition
In Infections ... like HIV, mycobacterial infections (TB), and parasitic infections like Leishmania and Malaria
Term
Function of Tregs ?
Definition
Suppress activation of immune system
Term
Deficiency of Tregs causes what problems ?
Definition
Severe autoimmune syndrome
Term
Function of the Fc segment part of a fusion protein ?
Definition
Adds stability and deliverability of the drug
Term
Ex fusion protein drug ?
Definition
Etanercept (Enbrel) , which is a TNF inhibitor that treats autoimmune diseases like RA, psoriasis, and ankylosing spondylitis
Term
All TNF Inhibitors are ?
Definition
Immunosuppressants
Term
Function of Infliximab (Remicade) ?
Definition
Is a monoclonal antibody TNF-inhibitor that treats autoimmune diseases like Crohn's disease, psoriasis, RA, and ankylosis spondylitis
Term
Function of Adalimumab (Humira) ?
Definition
TNF inhibitor for trt of autoimmune diseases like RA, psoriatic arthritis, ankylosing spondylitis, Crohns' disease, and ulcerative colitis.
Term
Function of Etanercept, Infliximab and Adalimumab ?
Definition
Are all TNF inhibitors
Treat autoimmune diseases like RA, Crohns' disease, and ankylosing spondylitis
Term
What is Abatecept (Orencia) ?
Definition
Fusion protein composed of IgG1 Fc segment and CTLA-4
Inhibits co-stimulation of T-cells
Is used to treat Rheumatoid Arthritis if TNF Inhibitors don't work
Term
What is Basiliximab (Simulect) ?
Definition
A chimeric CD25 (IL-2R) monoclonal antibody that prevents rejection in organ transplantation
Term
What is Daclizumab (Zenapax) ?
Definition
Humanized monoclonal antibody to the IL-2 receptor of T cells.
Used to prevent rejection in organ transp.
Term
What is Eculizumab ?
Definition
Humanized monoclonal antibody that is a terminal complement inhibitor first therapy approved for PNH (paroxysmal nocturnal hemoglobinuria).
Term
What is Golimumab (Simponi or CNTO 148) ?
Definition
Human monoclonal antibody TNF inhibitor that is used as an immunosuppressive drug
Used to treat RA, psoriatic arthritis, and ankylosing spondylitis
Term
What is Omalizumab (Xolair) ?
Definition
Humanized IgG1 monoclonal antibody that binds to IgE or mIgE (membrane IgE).
"inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds"
Used to treat severe allergic asthma
Term
What is Tofacitinib (Xeljanz) ?
Definition
JAK 3 Inhibitor , so interferes with JAK-STAT signalling pathway
Approved to treat RA (rheumatoid arthritis)
Term
Function of Rituximab (MabThera) ?
Definition
Anti-CD20 monoclonal antibody used to treat Non-Hodgkin Lymphoma, other lymphomas, and leukemias
Term
What is CDP571 ?
Definition
Human monoclonal antibody against TNF-alpha, used to treat Crohns' disease
Term
What is PF-956980 ?
Definition
Selective inhibitor of JAK 3
Term
What is Natalizumab (Tysabri) ?
Definition
Humanized monoclonal antibody against VLA-4 integrin.
Prevents VLA-4 to bind to VCAM-1
Trt for multiple sclerosis and Crohns' disease
Term
Reed Sternberg cells are seen in what disease ?
Definition
Hodgkin's Lymphoma
Term
Bence Jones proteins and Roleaux formation is seen in what disease ?
Definition
Multiple Myeloma
Term
Is put on CARs to increase signal transduction ?
Definition
CD3
Term
Function of CD137 (4-1BB) ?
Definition
Good stimulator of T-cells and increases IL-2 secretion survival and increases cytolytic activity
Term
What is Benlysta (Belimumab or LymphoStat-B) ?
Definition
Is an anti BLYS or BAFF monoclonal antibody.
Used to treat SLE
Term
Function of Ustekinumab (CNTO 1275 or Stelara) ?
Definition
Human monoclonal antibody directed against IL-12 / p40 and IL-23.
Term
Another name of p40 ?
Definition
IL-12B
Term
EBV secretes a protein that is a cytokine homologue. Homologue for which cytokine ?
Definition
IL-10
Term
For anyone on TNF blockers, make sure to monitor patients for ?
Definition
Fungal infections
Term
Anti-C5 antibody can be used to treat ?
Definition
PNH
Term
Pts. who take anti-CD5 Abs are susceptible to ?
Definition
Neisseria Meningitiditis
b/c you can't form C5 so can't form MAC complex
Term
Deficiency of CD 132 would be same as deficiency of ?
Definition
JAK 3
Term
Deficiency of CD 132 would be same as deficiency of ?
Definition
JAK 3
Term
6 receptors that share the CD 132 chain ?
Definition
2 4 7 9 15 21
IL-2R
IL-4R
IL-7R
IL-9R
IL-15R
IL-21R
Term
What is only type of transplant rejection you can treat with drugs ?
Definition
Acute rejection
Term
For Lyme disease (Borrelia Burgdorferi), immune system looks for what gene ?
Definition
VIse gene
Term
Defect in T cells will cause a defect in ?
Definition
B cell formation
Term
Tofcatinib or Xeljanz(JAK 3 inhibitor) induces secretion of what cytokine by CD4+ T-cells ?
Definition
TGF-B
Term
Another name for CD 31 ?
Definition
PECAM
Term
Another name for CD 25 ?
Definition
IL-2R (IL-2 receptor)
binds to IL-2 to promote T-cell proliferation
Term
Anti-CD25 or (Anti IL-2R) can be used to treat what brain disease ?
Definition
Multiple Sclerosis
Term
Anti p40 or anti-IL 12 or anti-IL 23 antibody is used to treat what brain disease ?
Definition
Multiple Sclerosis
The drug prevents IL-12 from activating NK cells to secrete IFNgamma and thus decrease Th1 cells formation
Term
Thick red skin with silvery scales can indicate what disease ?
Definition
Psoriasis
Term
What is molecular mimicry ?
Definition
Virus derived peptide causes T-cells to mediate self-directed responses and an antiviral response
Term
What is molecular mimicry ?
Definition
Virus derived peptide causes T-cells to mediate self-directed responses and an antiviral response
Term
Antibody - Antigen binding forms what ?
Definition
Immune Complex
Term
What cells eliminate immune complexes ?
Definition
Phagocytes
Term
What happens if immune complexes become too large and cannot be eliminated ?
Definition
Frustrated Phagocyte Effect
Term
What happens if immune complexes become too large and cannot be eliminated ?
Definition
Frustrated Phagocyte Effect
Term
IL-10 downregulates what cytokine ?
Definition
IL-12
Term
Which immune cells secret TNF ?
Definition
Activated Th1 cells
Activated Macrophages
Term
What is Eculizumab (Soliris) ?
Definition
Human monoclonal anti-C5 antibody used to treat PNH
Term
Mutation in CD132, gamma common chain, or JAK 3 can cause what disease ?
Definition
X-SCID
Term
Acute transp. rejection can be treated how ?
Definition
Inhibiting CD4+ Th1 cells or their cytokines
Term
Xolair or Omalizumab is what type of antibody ?
Definition
Monoclonal Anti-IgE antibody used to treat moderate to sever asthma
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