Term
| How does Rickettsia Rickettsii evade immune system ? |
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Definition
| Escapes to the phagocytic cytosol |
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Term
| How does Shigella evade immune system ? |
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Definition
| Toxin destroys endothelial cells and macrophages |
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Term
| How does Streptococcus Pneumoniae evade immune system ? |
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Definition
| Uses a polysaccharide capsule |
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Term
| How does Mycobacterium Tuberculosis evade immune system ? |
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Definition
| Inhibits fusion of phagosome and endosome with lysosomes |
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Term
| How does Borrelia Burgdorferi evade immune system ? |
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Definition
| VIsE (varible major protein like sequence) expressed |
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Term
| CCR5 antagonists block HIV infection how ? |
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Definition
| Block binding of gp 120 protein |
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Term
| What cytokines enhance macrophage cytotoxicity ? |
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Definition
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Term
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Definition
IL-2 receptor
Used as a marker to identify CD4+ FoxP3 Treg cells.
Expressed in some B cell neoplasms and TILS |
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Term
| Tregs is a good therapy for what diseases ? |
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Definition
A C O
Autoimmune disease
Cancer
Organ transplantation |
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Term
| Tregs is a bad therapy for what diseases ? |
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Definition
| In Infections ... like HIV, mycobacterial infections (TB), and parasitic infections like Leishmania and Malaria |
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Term
|
Definition
| Suppress activation of immune system |
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Term
| Deficiency of Tregs causes what problems ? |
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Definition
| Severe autoimmune syndrome |
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Term
| Function of the Fc segment part of a fusion protein ? |
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Definition
| Adds stability and deliverability of the drug |
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Term
|
Definition
| Etanercept (Enbrel) , which is a TNF inhibitor that treats autoimmune diseases like RA, psoriasis, and ankylosing spondylitis |
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Term
|
Definition
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Term
| Function of Infliximab (Remicade) ? |
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Definition
| Is a monoclonal antibody TNF-inhibitor that treats autoimmune diseases like Crohn's disease, psoriasis, RA, and ankylosis spondylitis |
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Term
| Function of Adalimumab (Humira) ? |
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Definition
| TNF inhibitor for trt of autoimmune diseases like RA, psoriatic arthritis, ankylosing spondylitis, Crohns' disease, and ulcerative colitis. |
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Term
| Function of Etanercept, Infliximab and Adalimumab ? |
|
Definition
Are all TNF inhibitors
Treat autoimmune diseases like RA, Crohns' disease, and ankylosing spondylitis |
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Term
| What is Abatecept (Orencia) ? |
|
Definition
Fusion protein composed of IgG1 Fc segment and CTLA-4
Inhibits co-stimulation of T-cells
Is used to treat Rheumatoid Arthritis if TNF Inhibitors don't work |
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Term
| What is Basiliximab (Simulect) ? |
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Definition
| A chimeric CD25 (IL-2R) monoclonal antibody that prevents rejection in organ transplantation |
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Term
| What is Daclizumab (Zenapax) ? |
|
Definition
Humanized monoclonal antibody to the IL-2 receptor of T cells.
Used to prevent rejection in organ transp. |
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Term
|
Definition
| Humanized monoclonal antibody that is a terminal complement inhibitor first therapy approved for PNH (paroxysmal nocturnal hemoglobinuria). |
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Term
| What is Golimumab (Simponi or CNTO 148) ? |
|
Definition
Human monoclonal antibody TNF inhibitor that is used as an immunosuppressive drug
Used to treat RA, psoriatic arthritis, and ankylosing spondylitis |
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Term
| What is Omalizumab (Xolair) ? |
|
Definition
Humanized IgG1 monoclonal antibody that binds to IgE or mIgE (membrane IgE).
"inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds"
Used to treat severe allergic asthma |
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Term
| What is Tofacitinib (Xeljanz) ? |
|
Definition
JAK 3 Inhibitor , so interferes with JAK-STAT signalling pathway
Approved to treat RA (rheumatoid arthritis) |
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Term
| Function of Rituximab (MabThera) ? |
|
Definition
| Anti-CD20 monoclonal antibody used to treat Non-Hodgkin Lymphoma, other lymphomas, and leukemias |
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Term
|
Definition
| Human monoclonal antibody against TNF-alpha, used to treat Crohns' disease |
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Term
|
Definition
| Selective inhibitor of JAK 3 |
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Term
| What is Natalizumab (Tysabri) ? |
|
Definition
Humanized monoclonal antibody against VLA-4 integrin.
Prevents VLA-4 to bind to VCAM-1
Trt for multiple sclerosis and Crohns' disease |
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Term
| Reed Sternberg cells are seen in what disease ? |
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Definition
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|
Term
| Bence Jones proteins and Roleaux formation is seen in what disease ? |
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Definition
|
|
Term
| Is put on CARs to increase signal transduction ? |
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Definition
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Term
| Function of CD137 (4-1BB) ? |
|
Definition
| Good stimulator of T-cells and increases IL-2 secretion survival and increases cytolytic activity |
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Term
| What is Benlysta (Belimumab or LymphoStat-B) ? |
|
Definition
Is an anti BLYS or BAFF monoclonal antibody.
Used to treat SLE |
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Term
| Function of Ustekinumab (CNTO 1275 or Stelara) ? |
|
Definition
| Human monoclonal antibody directed against IL-12 / p40 and IL-23. |
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Term
|
Definition
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|
Term
| EBV secretes a protein that is a cytokine homologue. Homologue for which cytokine ? |
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Definition
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|
Term
| For anyone on TNF blockers, make sure to monitor patients for ? |
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Definition
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Term
| Anti-C5 antibody can be used to treat ? |
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Definition
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|
Term
| Pts. who take anti-CD5 Abs are susceptible to ? |
|
Definition
Neisseria Meningitiditis
b/c you can't form C5 so can't form MAC complex |
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Term
| Deficiency of CD 132 would be same as deficiency of ? |
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Definition
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|
Term
| Deficiency of CD 132 would be same as deficiency of ? |
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Definition
|
|
Term
| 6 receptors that share the CD 132 chain ? |
|
Definition
2 4 7 9 15 21
IL-2R
IL-4R
IL-7R
IL-9R
IL-15R
IL-21R |
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Term
| What is only type of transplant rejection you can treat with drugs ? |
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Definition
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|
Term
| For Lyme disease (Borrelia Burgdorferi), immune system looks for what gene ? |
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Definition
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|
Term
| Defect in T cells will cause a defect in ? |
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Definition
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Term
| Tofcatinib or Xeljanz(JAK 3 inhibitor) induces secretion of what cytokine by CD4+ T-cells ? |
|
Definition
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|
Term
|
Definition
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Term
|
Definition
IL-2R (IL-2 receptor)
binds to IL-2 to promote T-cell proliferation |
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Term
| Anti-CD25 or (Anti IL-2R) can be used to treat what brain disease ? |
|
Definition
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|
Term
| Anti p40 or anti-IL 12 or anti-IL 23 antibody is used to treat what brain disease ? |
|
Definition
Multiple Sclerosis
The drug prevents IL-12 from activating NK cells to secrete IFNgamma and thus decrease Th1 cells formation |
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Term
| Thick red skin with silvery scales can indicate what disease ? |
|
Definition
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Term
| What is molecular mimicry ? |
|
Definition
| Virus derived peptide causes T-cells to mediate self-directed responses and an antiviral response |
|
|
Term
| What is molecular mimicry ? |
|
Definition
| Virus derived peptide causes T-cells to mediate self-directed responses and an antiviral response |
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Term
| Antibody - Antigen binding forms what ? |
|
Definition
|
|
Term
| What cells eliminate immune complexes ? |
|
Definition
|
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Term
| What happens if immune complexes become too large and cannot be eliminated ? |
|
Definition
| Frustrated Phagocyte Effect |
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Term
| What happens if immune complexes become too large and cannot be eliminated ? |
|
Definition
| Frustrated Phagocyte Effect |
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Term
| IL-10 downregulates what cytokine ? |
|
Definition
|
|
Term
| Which immune cells secret TNF ? |
|
Definition
Activated Th1 cells
Activated Macrophages |
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Term
| What is Eculizumab (Soliris) ? |
|
Definition
| Human monoclonal anti-C5 antibody used to treat PNH |
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Term
| Mutation in CD132, gamma common chain, or JAK 3 can cause what disease ? |
|
Definition
|
|
Term
| Acute transp. rejection can be treated how ? |
|
Definition
| Inhibiting CD4+ Th1 cells or their cytokines |
|
|
Term
| Xolair or Omalizumab is what type of antibody ? |
|
Definition
| Monoclonal Anti-IgE antibody used to treat moderate to sever asthma |
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