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SGU Immuno Cytokines
From lecture 10, fall 2009
19
Health Care
Graduate
10/04/2009

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Cards

Term
IL-1 and TNF
Definition
INFLAMMATION
Activate Mphage to secrete IL-1,6,12,TNF
and
Chemokines IL-8, MCP-1
Chemokine denovo expess ICAM-1, VCAM-1, E-Selectin and enhance ICAM-2 adn secrete chemokines IL-8 and MCP-1
Term
TNF
(alone)
Definition
Enhances NADPH oxidase activity

Activates iNOS with 2nd signal
Term
IL-2
Definition
Growth factor for T cells

Enhances NK cytotoxicity

Helps pCTL-->CTL

Inhibitory for Th17
Term
IL-3
Definition
Hematopoesis:
need for BOTH myeloid and lymphoid progenitor cell development
Term
IL-4
Definition
Required to switch to IgE
Downregulates Th1
Downregulates iNOS (nt as gud as TFGB)
Shifts Th0 response --> Th2
Term
IL-5
Definition
EOSINOPHILs !

Hematopoesis: differentiation of eosin.
Chemotactic for eosinophile
Activation of eosinophils
Term
IL-6
Definition
Stimulates secretion of CRP from hepatocytes (inflammation)

With TGFB leads to diff of Th0-->Th17 (pro-inflammatory!)
Term
Hematopoesis
Definition
T cells in the thymus
Term
IL-10
Definition
Downregulation of IL-12 by dendritic cells and m-phages

Th1 cytokines

Downregulates iNOS (not as gud as TGFB)
Term
IL-12
Definition
Activates NK cells to secrete IFNgamma
Term
IFNgamma
Definition
Activaes iNOS
Enhances activation of NADPH oxidase

Downregulates Th2
Critial for Th0-->Th1

With IL-2 promotes pCTL-->CTL

Enhances expression of MHC I and II
Term
IFNalpha IFNbeta
Definition
Triggers production of enzmes that interfere with replication of some viruses

Inhibition of T cell proliferation

Increase expression of Class I MHC

(2'5'oligoadenylate synthetase)
Term
TGFbeta
Definition
Downregulates iNOS

Critical for Th0 --> Tregs

WHEN PRESENT WITH IL-6
Differntiates Th0 --> Th17
Term
IL-17-A IL-1-F
Definition
Induce expr. of PROinflammatory cytokines and chemokines frm wide range of cells (IL-6, IL-8, GM-CSF, G-CSF, metlloproteinases from mphages and others

Autoimmune disorders if Th17 cells not specific for self antigen

Chemotacti for Neutrophils
Term
IL-21
Definition
With TGFB diferentiates Th0 -->Th17

Growth factor (amplification) of Th17 cells
Term
IL-22
Definition
Proinflammatory
Term
GM-CSF
Definition
Hematopoesis

Diferentiation of myeloid progenitor to GM progenitor
Term
G-CSF
Definition
Hematopoesis

Differentiation of GM progenitor to granulocyte/neutrophil
Term
M-CSF
Definition
Hematopoesis

GM progenitor --> monocyte
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