Risperidone

• Risperdal
• Starting dose: 1-2
• Dose range: 2-6
• Max dose: 16 
• Note: risk of EPS > 6mg
• Metabolism: 2D6 (major); 3A4 (minor)  

Paliperidone

• Invega
• Starting dose: 6
• Dose range: 6-12
• Max dose: 12
• Note: Food ↑ bioavailability by 60%
• Metabolism: 2D6 (major); 3A4 (minor)

Olanzapine

• Zyprexa
• Starting dose: 2.5-10
• Dose range: 5-20
• Max dose: 20
• Metabolism: 1A2 (major); 2D6 (minor)

Ziprasidone

• Geodon
• Starting dose: 20 bid with food
• Dose range; 120-160
• Max dose: 160
• Note:↑ q 2 days, 500 cal food required
• Metabolism: 2/3 aldehyde oxidase; 1/3 3A4

Quetiapine

• Seroquel
• Starting dose: 25mg bid
• Dose range: 300-800
• Max dose: 800
• Note: 2-3 divided doses with light meal or snack
• Metabolism: 3A4 (major); 2D6 (minor)

Aripiprazole

• Abilify
• Starting dose: 10-15
• Dose range: 10-15
• Max dose: 30
• Note: ↑ q 2 week
• Metabolism: 2D6 (major); 3A4 (major)

Clozapine

• Clozaril
• Starting dose: 12.5-25
• Dose range: 300-450
• Max dose: 900
• Note:↑ q25-50mg/d; qd or bid
• Metabolism: 1A2 (major); 2D6,3A4,2C19 & others (minor) 

Asenapine

• Saphris
• Starting dose: 5 bid subling
• Dose range: 5 bid
• Max dose: 5 bid
• Notes: Do NOT swallow, no eating & drinking for 10 min
• Metabolism: 1A2 (major); 3A4 (minor)

Iloperidone

• Fanapt
• Starting dose: 1 bid
• Dose range: 12-24
• Max dose: 24
• Notes:↑2mg/day due to orthostatic hypotension
• Metabolism: 2D6; 3A4