Term
|
Definition
direct contact with spirochete
can spread to any surface of body after contact
Development of immunity cannot prevent reinfection |
|
|
Term
|
Definition
|
|
Term
|
Definition
Disseminated infection
Rash (hands and feet)
lymphadenopathy
condylomata lata |
|
|
Term
|
Definition
asymptomatic
on gonig organ damage occurs
CAN STILL BE TRANSMITTED |
|
|
Term
|
Definition
neurosyphilis
CV
gummas (granulomatous inflammation) |
|
|
Term
|
Definition
Rapid Plasma Test (RPR)
Veneral Disease Research Lab (VDRL)
Very sensitive
Can be neg. early in infection
False + 1%, more common during pregnancy |
|
|
Term
|
Definition
Treponemal specific test
(FTA-ABS)
(TP-PA)
Darkfield micro (not as common anymore b.c syphilis not as popular) highly specific |
|
|
Term
|
Definition
Pen G
Repeat serology at 6 adn 12 mo.
Azithromycin in pen G allergic patients |
|
|
Term
Syphilis
Treatment
latent and during pregnancy |
|
Definition
Pen G
in pregnancy use even if mother is allergic |
|
|
Term
Herpesviridae
Characteristics |
|
Definition
double stranded linear DNA
assemble of nucleocapsid in cell nucleus
latent infection
destroys cell |
|
|
Term
Herpesviridae
Transmission HSV1 HSV2 |
|
Definition
Direct
most asymptomatic
viral DNA poly syn. |
|
|
Term
|
Definition
most of pop has
prevalence related to age
rising cause of genital herpes |
|
|
Term
|
Definition
17% of pop
most asymptomatic |
|
|
Term
Herpesviridae
Clinical
Initial &
Recurrent |
|
Definition
Initial
no antibodies in primary
non primary, prior exposure to heterologous virus
recurrent; prior exposure to homologous virus |
|
|
Term
|
Definition
mucocutaneous infection
ganglia (dorsal root)
asymptomatic shedding |
|
|
Term
Herpesviridae
Presentation |
|
Definition
Prodrome: itching, burning, tingling
Lesions: vesicles which rupture. PAINFUL ulcers
lesions can look like anything |
|
|
Term
Herpesviridae
Diag. (2 main) |
|
Definition
viral culture - gold standard; neg. results do not rule out, sensitivity limited due to shedding time
Serology - anti. to gG1 and gG2 |
|
|
Term
Herpesviridae
Treatment to initial episode |
|
Definition
HSV2 - can have symptoms and not know have HSV2
treatment reduces duration and severity |
|
|
Term
Herpesviridae
Treatment to recurrent episode (Episodic) |
|
Definition
1. Treat at first sign of symptoms
2. Treat all the time to minimize risk of lesion |
|
|
Term
Herpesviridae
Vertical transmission |
|
Definition
| 50% symptomatic on first episode b.c no antibodies |
|
|
Term
|
Definition
majority at delievery
post natal transmission can occur |
|
|
Term
Human Papillomavirus
Characteristics/Epi |
|
Definition
30% in US
double stranded DNA
worldwide
cancer: types 16, 18
warts, types 6, 11 |
|
|
Term
Human Papillomavirus
Diag. |
|
Definition
warts - appearance
cervical dysplasia - abnormal cytology
PCR |
|
|
Term
Human Papillomavirus
Treatment |
|
Definition
remove warts
virus NOT eradicated
cryotherapy
Trichloroacetic acid (TCA) (BCA)
surgical removal |
|
|
Term
Human Papillomavirus
Vaccination |
|
Definition
Quadravalent vaccine
11-12 yo |
|
|
Term
|
Definition
DNA Pox
salmon colored
central umbilication |
|
|
Term
|
Definition
MOST common reported infectous disease
intracellular
more common in women |
|
|
Term
|
Definition
bligate intracellular parasite
elementary bodies; infectious
reticular bodies; in host
distinguished from other clam by inclusions containing glycogen |
|
|
Term
|
Definition
Tissue: standard, 60-90 sensitive, don't use swabs with wood sticks
Direct immunoflorescence
EIA: 85 sensi.
Nucleic amplification assays (NAATs): test of choice
PCR/LCR 95 sensi. |
|
|
Term
Chlamydia
Clinical
LGV (Ulcer) |
|
Definition
uncommon systemic, rare in US
HIV more common |
|
|
Term
Chlamydia
Clinical
Urogenital Tract Infection (3) |
|
Definition
1. urethritis - discharge, dysureia
2. mycopurulent cervicitis - purulent or mucopurulent endocervical exudate visible in endocervical canal, AND sustained encocervical bleeding easily induced
3. PID - upper female genital tract; affects pregnancies |
|
|
Term
Chlamydia
Clinical
Men v Women |
|
Definition
Men are symptomatic early
Women asymptomatic until complication arises (PID) |
|
|
Term
Chlamydia
Clinical
During Pregnancy |
|
Definition
preterm delivery
postpartum infection
conjunctivitis!
6070% of newborns infected |
|
|
Term
Chlamydia
Treatment
Urethritis/Cervicitis
LGV
PID |
|
Definition
Urethritis/Cervicitis - Azithro or Doxy
LGV - Doxy
PID - broad spec. anti. |
|
|
Term
|
Definition
gram neg.; nonmotile; diplococci
coffee bean shaped
ox. positive
only utilize glucose
easily alter antigen structure |
|
|
Term
|
Definition
| 2nd most common reported infection disease in US |
|
|
Term
|
Definition
infects mucosal surfaces; columnar or cuboidal epi.
infects cervix and not vag. |
|
|
Term
|
Definition
endocervical specimen Gram Stain: very sensitive in men, less in women (DO NOT USE); leukocytes Culture: test of choice, dacron or rayon swab, modified Thayer Martin media, limited sensitivity NA Probe: high sens and specicifity
NAATs: test of choice PCR/LCR |
|
|
Term
|
Definition
similar to clymidea
men symptomatic, women asympt. until PID, etc
urethritis
mucopurulent cervicitis
PID |
|
|
Term
| Gonorrhea During Pregnancy |
|
Definition
complication more common in women with infection
septic spontaneous abortion
preterm neonatal ophthalamia neonatorum |
|
|
Term
|
Definition
Cefixime or Ceftraiaxone
FLUOROQUINIOLONES no LONGER RECOMMENDED
Cephalosporin in pregnant women
10-30% have chlamydia, TREAT FOR BOTH |
|
|
Term
Gonorrhea
Disseminated Infection |
|
Definition
bacterimia
petechial or pustular skin lesion, arthralgias
pregnant women: fatal endocarditis |
|
|
Term
Trichomonas Vaginalis
Characteristics |
|
Definition
direct genital contact
5-10% in men and women
frothy discharge |
|
|
Term
Trichomonas Vaginalis
Diag. |
|
Definition
| Wet prep, moves around slide. |
|
|
Term
Trichomonas Vaginalis
Treatment |
|
Definition
metronidazole
treat partners |
|
|
Term
| Chlymidia, gonherria, syphilis, Herpes (HSV1 & HSV2), PID |
|
Definition
|
|
Term
Bacterial Vaginosis
Skipped in lecture from 08
Characteristics |
|
Definition
Most prevalent casue of vaginal discahge
50% women asymptomatic
treatment of males do not benefit prevention |
|
|
Term
| Today, I received my passport in the mail. They got my birthdate wrong. Then I picked up my birth certificate that I had sent in with the application. Turns out my parents have been celebrating my birthday on the wrong day for 16 years. |
|
Definition
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