Term
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Definition
-Antiestrogen (blocks feedback on LSH)
Tx: Ovarian failure (fertility drug)
*Used if infertility is the result of excessive estrogenic inhibition
Sfx: Can overstimulate |
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Term
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Definition
-Replacement FSH and LH for women who don't make it (causes follicular stimulation)
*Used to simulate FSH, followed (14 days later) by a single injection of hCG to simulate LH |
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Term
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Definition
| -Mimics LH surge to induce ovulation |
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Term
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Definition
GnRH analog
Tx: Infertility resulting from hypothalamic amenorrhea. A pulsatile dosing (IV infusion) causes release of LH and FSH
Contraceptive: when given often desensitizes GnRH receptors (suppression of LH and FSH). |
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Term
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Definition
Syntheitic GnRH
Used as contraceptive or fertility drug (depending on how given) |
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Term
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Definition
-GnRH superagonist
Tx: Androgen dependent Prostate CA
Desensitizes GnRH receptors , reducing Testosterone (medical castration) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| GnRH Antagonist -Instead of desensitizing/just blocks Tx: management of infertility, prevents premature LH surge |
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Term
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Definition
| -Estradiol that is active orally |
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Term
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Definition
Orally effective pro-drug
-demethylated to ethinyl estradiol |
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Term
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Definition
Watersoluble with charge sulfate
-Slowly absorbed in the gut |
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Term
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Definition
| Non-steroidal plant derivatives w/ estrogen like activity |
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Term
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Definition
oral active nonsteroidal estrogen
-Increase risk of clear cell CA and cervical adenoma |
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Term
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Definition
Functional competitive Estrogen receptor antagonist (SERM)
-Prevent breast cancer (lowers LDL too) ^ bone density
Sfx: ^ risk of endometrial CA |
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Term
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Definition
Fxnal competitive Estrogen receptor antag
-Better than Tamoxifen on uterine tissue |
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Term
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Definition
Steroidal Aromatase Inhibitor
(lowers production of E2)
-adjuvant with tamoxifen |
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Term
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Definition
Non-steroidal aromatase inhibitor
-Postmenopausal women w/ BrCA who are in risk of recurrence |
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Term
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Definition
-Less thromboembolic events
-Higher incidence of cardiac events and hot flashes |
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Term
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Definition
| Non-steroidal aromatase inhibitor |
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Term
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Definition
| Added to conjugated E2 for HRT to blunt E2 effect on uterine tissue |
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Term
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Definition
| 19-nor progestin, has oral activity, but also active at androgen receptors |
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Term
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Definition
| 19-nor derivative that is less active at androgen (hirsuitism) |
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Term
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Definition
Competitive Antagonist at Progesterone and glucocorticoid receptors
*abortion pill (break down endometrium)
- |
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Term
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Definition
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Term
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Definition
-Promotes weight gain after surgery
Sfx: ^LDL and decrease HDL |
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Term
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Definition
Non-steroidal anti-androgen
Tx: prostatic CA
Can be used to w/ leuprolide to block effects of adrenal androgens |
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Term
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Definition
non-steroidal anti-androgen
-less hepatotoxic than flutamide |
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Term
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Definition
5-alpha reductase inhibitor
Prevents testosterone from becoming dihydrotestosterone
Tx: BPH and male pattern baldness |
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Term
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Definition
Progestin-only contraceptive (subdermal implant)
-can get infertility upon withdrawal |
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Term
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Definition
Post-Coital Emergency Contraception
-Prevents ovulation, fertilization, and possibly implantation |
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Term
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Definition
Steroidal anti-androgen (Prostate CA)
Weak Partial agonist at testoterone androgen receptor
Sfx: Inhibit libido and spermatogenesis |
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