It's important to have a healthy life style!!

The max life span is determined by

fibroblasts

They do not devide and differentiate forever

Normal Aging

Presbyopia:  our lenses are less flexible to accomodate near vision.

occur between 45-60 yrs

can be corrected by reading glasses

Height

average loss of 10 cm in height

due to

disc thinning out

less spongy and entire spine shrinks

Activeness

decline in activeness and endurance with age

crucial to keep your muscle active

they support your joints and help you stay mobile

Molecular biology of aging:

Telomeres: become shorter and shorter each time DNA replicate

Telomerase: the only enzyme that replenish the telomeres

Cell Senescence: adult gene run out of telomeres and become inactive.

Apotosis

Calori restriction

Free Radicals: old mitocohondria leak out more free radicals

Y chromosome: male with shorter arms live longer than female