Term
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Definition
endogenous
made from tryptophan
neurotransmitter
widely found in nature |
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Term
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Definition
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Term
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Definition
| Platelets uptake 5-HT and store it in secretory granules. Platelet aggregation triggers 5-HT release and vasoconstriction |
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Term
| Carcinoid tumor and serotonin |
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Definition
| psychotic behaviors may result from tumors of the enterochromaffin cells that excrete high amounts of 5-HT into circulation |
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Term
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Definition
Five members
expressed by neurons in the CNS
G protein coupled receptors
Inhibit adenylate cyclase
regulate ion channels
inhibit neuronal 5-HT release |
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Term
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Definition
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Term
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Definition
G protein coupled
Activate PL-c
Increase intracellular calcium
brain, gut, and platelets |
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Term
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Definition
Methysergide
ketanserin
cyproheptadine |
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Term
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Definition
ligand gated ion channels
Cause cell depolarization
brain, GI tract, spurs emetic response |
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Term
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Definition
GProtein coupled
activate adenylate cyclase
CNS and GI tract
mediate secretion and peristalsis |
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Term
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Definition
e.g. Sumatriptan
used for acute treatment of migraine, not prophylaxis
contra in patients with CV, brain dz
Raise serotonin levels
SQ dosing to avoid nausea/vomit |
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Term
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Definition
serotonin excess that is fatal
SSRI + 'triptans
cognitive + autonomic dysfunctions |
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Term
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Definition
e.g. methysergide
used prophylactically for migraines but not a first line tx
long term therapy not good; metabolite is psychidelic, inflammatory fibrosis |
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Term
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Definition
e.g. ondansetron
treat nausea, but not motion sickness
Side effects: constipation |
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Term
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Definition
e.g. metoclopramide, mosapride
prokinetic, upper GI emptying
treats GERD and IBS
relieves GI dysmotility syndromes
anti-dopaminergic effect |
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