Shared Flashcard Set

Details

Serology test 1- autimmune
autoimmune disorders
38
Health Care
Undergraduate 4
04/05/2009

Additional Health Care Flashcards

 


 

Cards

Term
antibodies that react with an individual's own endogenous antigenic determinants
Definition
autoantibodies
Term
two genetic factors influencing autoimmune disease
Definition
familial tendencies and HLA associations
Term
What kind of antibodies are present in autoimmune hemolytic anemia?
Definition
erythrocyte antibodies; antibodies directed against red cells
Term
what test is used to detect autoimmune hemolytic anemia?
Definition
direct antiglobulin test
Term
in idiopathic thrombocytopenic purpura (ITP), what are the antibodies directed against?
Definition
antibodies directed against platelets causing shortened platelet survival
Term
What antibodies are present in Hashimoto's disease?
Definition
cytotoxic antibodies directed against thyroglobulin
Term
what autoimmune disease causes painless enlargement of the thyroid and is 10 to 15 times more frequent in females?
Definition
Hashimoto's
Term
What autoimmune disease causes hypothyroidism?
Definition
Hashimoto's
Term
In Graves' disease, what is the antibody directed against?
Definition
cell surface thyroid stimulating hormone (TSH) receptors
Term
what autoimmune diseases are most common in females aged 20-40 years?
Definition
Graves' disease, SLE
Term
what autoimmune disease causes hyperthyroidism?
Definition
Graves' disease
Term
What autoimmune disease causes elevated T3, T4, and decreased TSH?
Definition
Graves' disease
Term
what antibody is present in pernicious anemia?
Definition
antibdoy directed against intrinsic factor (IF)
Term
what autoimmune disease interferes with the absorption of B12?
Definition
pernicious anemia
Term
The intrinsic factor antibodies in pernicious anemia are produced by what cells?
Definition
plasma cells in GI tract
Term
In infertility, antibodies are produced against what?
Definition
sperm
Term
what autoimmune disease causes aggregation of sperm?
Definition
infertility
Term
In Goodpasture's syndrome, what are the autoantibodies directed against?
Definition
Glomerular basement membrane
Term
what autoimmune disease is associated with glomerulonephritis, complement-fixing antibodies, and lung hemorrhage?
Definition
Goodpasture's syndrome
Term
In Myasthenia gravis, what are the autoantibodies directed against?
Definition
acetylcholine receptor
Term
what autoimmune disease is twice as common in females?
Definition
Myasthenia gravis
Term
what autoimmune disease causes abnormal neuromuscular transmission, muscle weakness and fatigability?
Definition
Myasthenia gravis
Term
what autoimmune disease has an HLA B8 association?
Definition
Myasthenia gravis
Term
what autoimmune disease has complexes of nuclear antigens, immunoglobulins and complement?
Definition
Systemic lupus erythematosus
Term
what autoimmune disease has immune complexes in circulation and in kidneys?
Definition
systemic lupus erythematosus
Term
what autoimmune disease is associated with decreased serum complement components C3 and C4?
Definition
Systemic lupus erythematosus
Term
what autoimmune disease is associated with increased sedimentation rate, increased serum gammaglobulins, positive ANA, abnormal urinalysis, LE cells?
Definition
systemic lupus erythematosus
Term
what autoimmune disease is associated with immunological hyperreactivity resulting in increase cellularity of synovial membranes?
Definition
rheumatoid arthritis
Term
what autoimmune disease is associated with an IgM antibody against IgG?
Definition
rheumatoid arthritis
Term
what autoimmune disease causes joint erosion?
Definition
rheumatoid arthritis
Term
what three types of tests can be used to detect autoantibodies?
Definition
immunofluorescence, agglutination tests, and radioimmunoassay (RIA)
Term
Three techniques used in treatment of autoimmune disorders
Definition
Metabolic control or replacement therapy, anti-inflammatorydrugs, and immunosuppressive drugs
Term
cyclosporin A, azathioprine, cyclophosphamide and methotrexate are all types of what?
Definition
immunosuppressive drugs
Term
steroids, salicylates, ibuprophen and gold salts are all types of what?
Definition
anti-inflammatory drugs
Term
vitamin B12 is used to treat what autoimmune disease?
Definition
pernicious anemia
Term
insulin is used to treat what autoimmune disease?
Definition
juvenile diabetes
Term
anti-thyroid drugs are used to treat what autoimmune disease?
Definition
Graves' disease
Term
Thymectomy is used to treat what autoimmune disease?
Definition
myasthenia gravis
Supporting users have an ad free experience!