Term
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Definition
| Brings in a functioning protein that bind to a protein hat modifies GDP |
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Term
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Definition
| keep RAS active all the time |
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Term
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Definition
| RAS stays active all the time because RAS can't be turned off |
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Term
| Why doesn't breast cancer use ras? |
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Definition
| It is related to growth factor receptor. Turns on the same pathway |
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Term
| G protein matches what protein in this pathway |
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Definition
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Term
| A new anticancer drug is being designed whose goal it to block cancer mediated by mutated Ras proteins. Which drug would be least effective |
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Definition
| One that blocks interaction o Ras with sos |
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Term
| What are Bone Morphogen proteins? |
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Definition
| Are groups of growth factors and cytokines that play critical roles in development, differentiation, proliferating, and apotosis |
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Term
| What does ligand binding cause in BMP signaling? |
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Definition
| Complex formation between two subunits of BMPR. Type II phosphorylates type I thenphosphorylates R-smad |
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Term
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Definition
| After being activated it enters the nucleus and enters the nucleus and regulates gene expression |
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Term
| The BMP can be bound by proteins that do what? |
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Definition
| These Noggin proteins come from other cells and can bind to BMP and regulate a neighbor cell. Slowing cell cell interaction. |
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Term
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Definition
| Suppresses active smad from inside the cell. Allows cross talk between pathways. |
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Term
| What biological processes use BMP? |
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Definition
Mineralization bone formation.
Embryonic development of skeletal ad non skeletal tissues. |
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Term
| What disorder is associated with altered noggin |
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Definition
| Signaling would go up. joint problems because of effect on BMP |
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Term
| What if there is a BMPR 1 mutaton |
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Definition
| Connective tissue diseases BC BMP doesn't function during development |
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Term
| What is sma4 is inactivated |
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Definition
| Cancer. Tumor suppressing |
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Term
| What are clinical BMP uses |
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Definition
| promote repair of bone defects. |
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