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Sensory-Taste
Dr.Ellis Taste Lecture
31
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Graduate
10/21/2010

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Cards

Term
What are the 5 sensations of taste?
Definition

1. Sour

2. Sweet

3. Salty

4. Umami

5. Bitter

Term
Sour taste is caused by _________
Definition

Acids

(H+ concentrations)

Term
Sweet taste is caused by __________
Definition

Not just one compound

sugars, glycols, alcohols, A.A

Term
Salt is caused by ___________
Definition

Na+ ions concentrations

or any cations

Term
Bitter taste is caused by _____________
Definition
Alkaloids and organic substances that have nitrogen in it
Term
Umami is in foods that have what?
Definition
L-glutamate
Term
What kinds of foods have Umami?
Definition
Meats and aging cheeses
Term

What is the taste threshold for humans?

(from lowest to highest)

Definition
Bitter> sour> sweet = salty
Term
Salty taste is trigger by NaCl that has a Na+ selective channel called what?
Definition

ENaC or

Amiloride-sensitive epithelial Sodium Channel

Term
When Na+ enters into the salt receptors what happens?
Definition
It depolarizes the membrane and creates a receptor potential
Term
When H+ enter for a sour taste what happens?
Definition

1. H+ enter to the ENaCs

2. Block K+ sensitive channels

3. Since a decrease in K+ can lead to a depolarization

4. Can also enter to the Hyperpolarization- activated cyclic nucleotide gated cation channel ( HCN)

Term
Umami taste is due to activation of what 2 kinds of receptors?
Definition

1. metabotropic glutamate

2. ionotropic glutamate

Term
Which metabotropic glutamate receptor is Umami taste?
Definition
mGluR4
Term
Umami receptors always produce a ____________
Definition
Depolarization
Term
If something is bitter it is best to __________
Definition
Avoid it
Term
Many bitter tastes come from_______?
Definition
Poisons
Term
What kind of receptors are included for a bitter taste?
Definition

1. K+ selective channels

2. T2R

Term
T2R are receptors that cause what?
Definition

1. G-protein aka gustducin

2. Binds and decreases cAMP

3. Increases IP3 and DAG

4. Creates a depolarization

Term
What is Quinine an example of?
Definition
a bitter compound that is permeable to the membrane
Term
What receptor is responsible for a sweet taste?
Definition
T1R3
Term
Where are taste buds located on the human tongue?
Definition
On the papilla
Term
What are the 3 types of taste buds?
Definition

1. Circumvallate

2. Foliate

3. Fungiform

Term
Fungiform taste buds are located at the ________
Definition
tip of the tongue
Term
Circumvallate taste buds are located at the ____________
Definition

Base of the tongue

(all the way in the back)

Term
What are the four ways to innervate the taste buds?
Definition

1. chorda tympani of the facial nerve

2. lingual branch of the glossopharyngeal nerve

3. Ventral posterior medial nucleus of thalamus

4. Gustatory cortex ( anterior insula frontal operculum)

Term
What kind of cells are in a taste bud?
Definition

1. Epithelial cells

2. Basal cells

3. Taste cells

4. Gustatory afferent nerve

Term
An absence of sense of taste is called
Definition
Ageusia
Term
Diminished taste sensitivity is called
Definition
Hypogeusia
Term
An unpleasant perception of taste is called
Definition
Dysgeusia or parageusia
Term
What are some things that causes Hypogeusia?
Definition

1. Damage to the lingual or glossopharyngeal nerve

2. Neurological disorder

3. infections like amoeboid meninogencephalopathy

4. Vitamin B3 deficiency

5. Zinc deficiency

6. Age

7. Tobacco abuse

Term
Dysgeusia is characterized by having what kinds of taste?
Definition

Metallic

Salty

Rancid

Foul

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