Term
| The three most serious adverse effects of penicillins are: |
|
Definition
| Allergic rxns, hematologic disorders, neurologic disorders (seizures) |
|
|
Term
| True or false: Ceftriaxone requires renal dosage adjustment. |
|
Definition
|
|
Term
| The most serious adverse effects of cephalosporins are: |
|
Definition
| Allergic rxns, hematologic disorders, neurologic disorders, disulfiram-like rxn (cefotetan) |
|
|
Term
| The most serious adverse effects of carbapenems are: |
|
Definition
| Diarrhea (C. difficile), allergic rxn (cross-sensitivity with PCNs is higher than with cephalosporins), seizures (imipenem) |
|
|
Term
| Major adverse effects of aminoglycosides includes: |
|
Definition
| Nephrotoxicity, ototoxicity, neuromuscular blockade |
|
|
Term
| The serious adverse effects of TMP-SMX is: |
|
Definition
| Hypersensitivity, crystallization resulting in kidney stones (contraindicated in renal failure), hematologic disorder (bone marrow suppression at high doses), contraindicated in pregnancy/breast feeding. |
|
|
Term
| The serious adverse effects of tetracyclines are: |
|
Definition
| Photosensitivity, discoloration of developing teeth, esophageal ulceration |
|
|
Term
| The major adverse effect of tigecycline is: |
|
Definition
|
|
Term
| True or False: Tigecycline does not require renal dose adjustment. |
|
Definition
| True. Tigecycline requires HEPATIC dose adjustment. |
|
|
Term
| The common adverse effects of macrolides are: |
|
Definition
| Nausea, abdominal pain (worse with erythromycin), metallic taste (clarithromycin) |
|
|
Term
| These macrolides have significant drug interactions with CYP3A4: |
|
Definition
| Erythromycin, Clarithromycin |
|
|
Term
| This ketolide is often associated with hepatic failure: |
|
Definition
|
|
Term
| The major adverse effects of the quinolones are: |
|
Definition
| CNS effects (dizziness), photosensitivity, arthropathy (contradicted < 18 y.o.), tendonitis/tendon rupture (Black Box Warning), QT interval prolongation |
|
|
Term
| These very common drugs interact with quniolones: |
|
Definition
| Multivalent metal cations (antacids, Fe supplements) |
|
|
Term
| Common adverse effects of clindamycin includes: |
|
Definition
| Diarrhea, C. difficile colitis, GI upset |
|
|
Term
| The most serious adverse effects of metronidazole include: |
|
Definition
| CNS effects, GI upset, Metallic taste, Disulfiram-like rxn |
|
|
Term
| Major adverse effects of chloramphenicol include: |
|
Definition
| Aplastic anemia (irreversible), bone marrow suppression (reversible), Gray Baby Syndrome (neonates) |
|
|
Term
| Chloramphenicol interacts with these drugs: |
|
Definition
| Warfarin, phenytoin. (P450 interaction) |
|
|
Term
| Common adverse effects of vancomycin include: |
|
Definition
| Nephrotoxicity, drug fever, Red Man syndrome |
|
|
Term
| Quinupristin/Dalfopristin interacts with: |
|
Definition
|
|
Term
| Major adverse effects of quinupristin/dalfopristin include: |
|
Definition
| Inflammation at infusion site, arthralgia/myalgia |
|
|
Term
| The major adverse effect of long-term use of linezolid is: |
|
Definition
|
|
Term
| Linezolid may interact with this class of drugs: |
|
Definition
|
|
Term
| The common adverse effect of daptomycin is: |
|
Definition
|
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