Term
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Definition
Fast acting Na channel blocker
for #1 = tonic clonic/status epilepticus, complex partial
binds during action potentials via PRESYNAPTIC INHIBITION
nonlinear elminiation, bound therefore avoid valproic acid
`1. sulfa drug, teratogen, BONE LOSS |
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Term
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Definition
Fast acting Na channel blocker
1. tonic clonic + bipolar + TRIGEMINAL NEURALGIA
autoinduces cyps
sulfa drug + ataxia + BONE LOSS |
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Term
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Definition
Non-typical Na channel blocker
partial
dizzyness/aseptic meningitis +skin |
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Term
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Definition
Fast Na blocker, weak Ca blocker
absense, mixed, complex partial
best for complicated therapy
INCREASES FREE PHENYTOIN
teratogen,hepatoxic,nause |
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Term
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Definition
T-type Ca2+ channel blockers
absense
gi distress, bone marrow fatique |
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Term
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Definition
Presynaptic Ca2 channel
partial
edema/weight gain |
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Term
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Definition
presynaptic Ca2+ channel
partial
NEUROPATHIC PAIN!!!!
mild euphoria, edema/weight gain |
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Term
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Definition
synaptic transmission modulator
for partial or generalized seizures (adjunct)
binds synaptic vesicle protein |
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Term
| paroxysmal depolarizing shifts |
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Definition
| slow long-lasting local depolarization that moves the neuron close to the threshold for Na channel activation |
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