Term
Depolarizing neuromuscular blocking agent
(1) |
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Definition
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Term
Non-depolarizing neuromuscular blocking agent
(3) |
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Definition
d-tubocurarine
cistracurium
rocuronium |
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Term
Centrally acting spasmolytics
(6) |
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Definition
Baclofen
cyclobenzaprine
carisoprodol
metaxalone
methocarbamol
tizadine |
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Term
| Direct acting muscle relaxant |
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Definition
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Term
| MOA for most sedative hypnotics |
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Definition
GABAA&B receptors
different subunits for different responses
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Term
| 2 major pharmacologic effects of ethanol in CNS |
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Definition
1. enhance action of GABA on GABAa receptors
2. inhibit ability of glutamate to open NMDA receptors |
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Term
effects of ethanol(non CNS)
(2) |
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Definition
heart- depression of contractility
smooth muscle- vasodilation in periphery |
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Term
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Definition
essential tremor
self treatment of anxiety/depression |
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Term
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Definition
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Term
| Why some benzos last longer than others |
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Definition
| they undergo hepatic metabolism and some have active metabolites with long half lives |
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Term
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Definition
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Term
| intermediate acting benzos |
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Definition
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Term
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Definition
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Term
| True or False: Benzos have related chemical structures |
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Definition
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Term
| Why are barbituates not commonly used as sedative hypnotics anymore? |
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Definition
| long half lives lead to accumulation/toxicity |
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Term
| MOA for non-benzo hypnotics |
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Definition
| bind go GABAa (different site then benzos) |
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Term
| kinetics of non-benzo hypnotics |
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Definition
rapidly absorbed
few metabolites
short half lives |
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Term
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Definition
| antagonist for benzos and non-benzo hypnotics |
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Term
| Clinical uses for sedative-hypnotics |
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Definition
sedation
hypnosis
anesthesia
anticonvulsant effects
muscle relaxation
effects on respiratory and cardiac function
(dose dependent) |
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Term
Physiological effects of Sedative-hypotics
Sedation |
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Definition
-reduce anxiety
-depressor effects on cognitive function
-anterograde amnesia |
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Term
Physiological effects of Sedative-hypotics
Hypnosis
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Definition
- induce sleep at higher doses
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Term
Physiological effects of Sedative-hypotics
Anesthesia
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Definition
high enough doses can be used for general anesthsia
BZ used in combo with other agents
Barbituates have favorable characteristics |
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Term
which sedative hypnotics are used as
anti convulsants
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Definition
phenobarbital
clonazepam
diazepam
lorazepam |
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Term
which sedative hypnotics are used as
muscle relaxants |
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Definition
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Term
Ramelteon (Rozerem)
MOA, uses |
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Definition
melatonin agonist
reduces sleep latency |
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Term
Buspirone (Buspar)
MOA, uses |
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Definition
serotonin and dopamine receptor
reduces anxiety (not acute) without sedation or euphoria |
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Term
| Other drug classes used as sedative-hypnotics |
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Definition
antihistamines
antidepressants
antipsychotic (quetiapine) |
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Term
Neuromuscular blocking agents
2 types |
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Definition
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