Term
| All of 2nd generation antipsychotics have what black box warning? |
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Definition
All have black box warning for risk of death in elderly with dementia.
All have black box wrning for suicidality if used as adjunctive treatment for resistant depression (olanzepine, ariprprazole). |
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Term
| All atypicals (and typicals) have what kind of cardiac risk? |
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Definition
QT prolongation risk - highest with thioridazine and the atypical agents ziprasidone, iloperiodone, paliperidone and asenapine. |
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Term
| Atypcials worse compared to typicals for NMS side effects? |
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Definition
| All have NMS side effects - but lower risk than with typicals. |
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Term
| All atypicals have EPS risk (compartivly less than typicals) except for which one? |
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Definition
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Term
| Which medicaiton has increased EPS risk if dosed >6 mg/d or less if used in elderly. |
|
Definition
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Term
| Atypicals may be more effective for which symptoms of schizophrenia? |
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Definition
|
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Term
|
Definition
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|
Term
| Brand name for Olanzapine |
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Definition
|
|
Term
| Brand name for risperidone |
|
Definition
|
|
Term
| Brand name for Quetiapine |
|
Definition
|
|
Term
| Most signifiant side effect of clozapine? |
|
Definition
Clozapine is thought to be the most effective aytpical, but use is limited due to risk of agranulocytosis and seizures |
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Term
| How is olanzapine administered? |
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Definition
| IM injection (acute agitation). It's an adjunctive Tx for depression. |
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Term
|
Definition
It's an inj suspension formulation of Olanzapine. It has restricted use - can cause sedation (including coma) and/or delirium after injection. |
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Term
| Brand name for risperidone? |
|
Definition
|
|
Term
| What's this medication's cliam to fame? |
|
Definition
First drug approved for autism.
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|
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Term
|
Definition
2 week injection, 25 - 50 mg (also as adjunct Tx for bipolar with either lithium or valproate) |
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Term
| What are Risperdal M - Tabs |
|
Definition
| Orally disintegrating Risperdal oral solution |
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Term
|
Definition
|
|
Term
| How is quetiapine XR taken? |
|
Definition
| XR is taken at night without food, or light meal (food increases absorption). |
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|
Term
| Brand name for Ziprasidone? |
|
Definition
|
|
Term
| How is Ziprasidone administered (dose too)? |
|
Definition
|
|
Term
| Name the contraindicaiton with ziprasidone |
|
Definition
| Prlongs QT interval and so contraindicated with QT risk. |
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|
Term
| Brand name for Aripiprazole |
|
Definition
|
|
Term
| What aripiprazole used for and what formulations does it come in? |
|
Definition
used as an antipsychotic, and for bipolar, and as an adjunctive tx for depression. It comes in tablets, solution and as an IM injection (Abilify Discmelt, ODT).
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|
Term
| Brand name for paliperidone |
|
Definition
|
|
Term
|
Definition
| long acting inj suspension formulation of Paliperidone |
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|
Term
| All antipsychotics can prolong the ___ interval? |
|
Definition
|
|
Term
| Which of the atypicals should be avoided in those with arrhythmias? |
|
Definition
Iloperidone, paliperidone, asenapine, risperidone (and all typicals especially thioridazine). |
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Term
| Because all antipyschotics can prolong the QT interval, what sort of drugs should be cautioned/avoided? |
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Definition
Dugs that deplete potassium or magnesium, since this will increase arrhythmia risk. These include diuretics, aminoglycosides, cyclosporine and amphoteracin.
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Term
| Avoid additive dopamine - blocking agents (metoclopramide, etc), especially in elderly. |
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Definition
| Statement. Not a question. |
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Term
| Avoid additive agents with CNS depression and sedation. |
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Definition
| Statement. Not a question. |
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Term
| Fluoxetine and paroxetine have been shown to increase the plasma oncentration of ______ up to 4-fold. |
|
Definition
|
|
Term
|
Definition
| Its an ODT (oral disentegrating tablet). Most ODTs contain phenyalanine and cannot be give to patients with phenylketonuria (PKU). |
|
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Term
| Which are associated with weight gain? |
|
Definition
Olanzapine
Clozapine
Risperidone
Quetiapine
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|
|
Term
|
Definition
New atypical antipsychotic developed for schizo. It's a sublingual tablet.
Place tablet under the tongue and allow it to dissolve completely. Tablet will dissolve in saliva within seconds. The tongue will feel numb afterwards. |
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Term
| How to take Abilify Discmelt, Risperdal M-Tab, Zyprexa Zydis? |
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Definition
Immediately upon opening the foil blister, using dry hands, remove tablet and place in mouth. Do not push the tablet through the foil because it may crumble. Table disintegration occurs rapidly so it can be easily swallowed with or without liquid. |
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Term
| How can ripserdal oral solution be administered? |
|
Definition
Can be administered directly from the calibrated pipette, or mixed with water, coffee, ornage juice, and low - fat milk; it is not compatible with cola or tea.
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Term
| How is Quetiapine XR taken? |
|
Definition
| Taken at night without food, or light meal. |
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|
Term
| How is olanzapine normally taken? |
|
Definition
generally taken once daily at night (QHS), since it is long - acting and sedating. |
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