Term
| What is scleroderma characterized by? |
|
Definition
| deposition of fibrous connective tissue |
|
|
Term
| What does CREST syndrome stand for? |
|
Definition
C-Calcinosis
R-Raynauds
E-Esophogeal involvement
S-Sclerodactly
T-Telangiectasias |
|
|
Term
| What is the best predictor of patients with Raynaud phenomenon developing scleroderma? |
|
Definition
| abnormal nail-fold capillary pattern and positive ANA |
|
|
Term
| progressive fibrosis, vascular abnormalities, and inflammation are common features of what? |
|
Definition
|
|
Term
| What are the first signs of scleroderma in the hands? |
|
Definition
| swelling and thickening of the fingers and hands |
|
|
Term
| What GI complication is present in 90% of Scleroderma patients? |
|
Definition
| Esophageal hypomotility (GERD) |
|
|
Term
| What is the most common cause of death in scleroderma? |
|
Definition
|
|
Term
| What are the most common pulmonary findings in Scleroderma? |
|
Definition
1) pulmonary vascular disease
2) interstitial inflammation and fibrosis |
|
|
Term
| What kidney problems are common with scleroderma? |
|
Definition
| chronic proteinuria and malignant hypertension |
|
|
Term
| What lab test is positive in 85% of scleroderma cases? |
|
Definition
|
|
Term
| What do you use to treat renal complications with scleroderma? |
|
Definition
|
|
Term
| dermatomyositis is characterized by what? |
|
Definition
| symmetrical proximal muscle weakness in all extremities, accompanied by a skin rash |
|
|
Term
| Myositis is most common with what other rheumatic disease? |
|
Definition
|
|
Term
| What is the most common pulmonary problem of inflammatory myopathies? |
|
Definition
| pneumonia from aspiration |
|
|
Term
| What autoantibodies are found in approximately 90% of inflammatory myopathy cases? |
|
Definition
| autoantibodies to nuclear and cytoplasmic antigens |
|
|
Term
| What is the mainstay drug therapy for inflammatory myopathies? |
|
Definition
| glucocorticoids (prednisone) |
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