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Science Foundations II
genetic structure
18
Health Care
Professional
11/29/2008

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Cards

Term
central dogma
Definition
DNA (transcription) RNA (translation) protein
Term
gene
Definition
fundamental unit of info, segment of DNA that encodes info
Term
genome
Definition
gene + intergenic (non-coding)DNA
Term
chromosome
Definition
packaged DNA, single, large nucleic acid molecules containing many genes that store and transmit genetic info
Term
viral genome
Definition
small, RNA or DNA, infectious parasites (not free-living)
Term
bacterial genome
Definition
1 circular double-stranded DNA, some have plasmids (smaller extrachromosomal elements)
Term
eukaryotic genome
Definition
in nucleus, larger and more complex, introns and exons, also have mitochondrial DNA - circular double stranded
Term
intron
Definition
intrinsic, intervening sequences, nontranscribed
Term
exon
Definition
expressed DNA (1.5% of human DNA)
Term
colinear DNA
Definition
does not contain introns, viral and prokaryotic DNA, histones
Term
histone
Definition
colinear DNA, role in packaging/protection of DNA and regulating accessibility of DNA, rich in basic aa (+ b/c DNA is -), undergoes post-translational modifications, position on DNA can affect expression
Term
centromere
Definition
attachment point for proteins during cell division
Term
telomere
Definition
end of chromosome, helps stabilize, not readily replicated, telomerase maintains length
Term
how is DNA compacted into small cell?
Definition
supercoiled, topoisomerase - enzyme to control extent of DNA supercoiling, wrap DNA around nucleosome, pack nucleosome into 30nM fiber, looping/folding/coiling further compact
Term
Type I topoisomerase
Definition
breaks one strand of DNA, rotates, then rejoins
Term
Type II topoisomerase (DNA gyrase)
Definition
breaks both strands of DNA, rotates, then rejoins
Term
chromatin
Definition
in nondividng cells, contains DNA, histones, small amount of RNA
Term
nucleosome
Definition
8(2 of 4 types)histones + DNA, ~200 bp, many = beads on a string, for protection and some compaction of DNA
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