Term
| Characteristics of Poxviradae? |
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Definition
| Large, Brick-shaped, uses virally encoded enzymes, viral DNA replicates in host cytoplasm |
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Term
| Variola (Small Pox) Characteristics? |
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Definition
| inhaled and replicates in URI, after 2 rds. of viremia=dermal and internal tissue seeded, variola major m. rate=15-40% and variola minor = 1% |
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Term
| What is the Vaccinia virus? |
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Definition
| similar to smallpox and is basis for modern attenuated vaccine |
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Term
| Characteristics of Herpesviradae? |
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Definition
| enveloped icosahedral nucleocapsids, many other animals have herpesviruses and some are oncogenic like Merek's Disease |
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Term
| What is Molluscum contagiosum? |
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Definition
| a pox virus that is transmitted through direct contact or formites, infects basal skin layer, tropical climates, kids, HIV+, mucous mem. lesions pearly white papules |
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Term
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Definition
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Term
| Types of alpha herpeviradae? |
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Definition
HSV-1=fever blisters, keratoconjunctivitis, encephalitis
HSV 2= STD, sacral ganglia in latent phase, transported via dicrectional cytoskeloton of neurons
Varicella=chicken pox
Herpes Zoster=shingles, cranial posterior root ganglia
Varicella-zoster(VZV)=virus used to make chicken pox vaccine |
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Term
| Types of Gamma Herpes Viruses? |
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Definition
| EBV and Human Herpes 8 (HHV-8) |
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Term
| EBV causes Heterophile Antibody Positive Infectious Mononucleosis, what is this? |
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Definition
| high fev, pharyngitis, malaise, swollen glands, heterophile antibody causes sheep and horse rbc agglut., B cell prolif controlled by CD8 Ts in atypical Downey Form, after infection subsides HA is gone but Igs specific for virus remain |
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Term
| What cancers are associated with EBV? |
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Definition
| Burkitt's Lymphoma, Hodgkin's Lymphoma, latently infected cells will express EBNA1 and LMPs, lymphomas can result from organ transplant especially in immunocompromised |
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Term
| What are charc. of Human Herpes Virus 8? |
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Definition
| causes Kaposi's Sarcoma (a B-cell lymphoma), especially in immunocompromised |
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Term
| What are the Beta Herpes Viruses? |
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Definition
| CMV, Human Herpes Virus 6 (HHV-6) and Human Herpes Virus 7 (HHV-7) |
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Term
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Definition
| causes heterophile antibody negative mono, jaundice, neurological damage in fetus, pneumonia and chorioretinitis in immunocompromised, latency in monocytes |
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Term
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Definition
| causes exanthum subitum=roseola infantum, most common childhood exanthem=3-5 day fever plus a maculopapular rash, latent in peripheral mononuclear cells (PMBC), sometimes chronic infection of salivary gland CD4s and epithelial cells |
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Term
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Definition
| orphan virus with no diease associated with it |
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Term
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Definition
| med size (90-100nm), 49 serotypes and 6 subgenera, Acute Respiratory Disease (military) common cold, LRT too, conjunctivitis in kids, cycstitis, gastroenteritis,left ventricular dysfunction, naked icosahedral nucleocapsid, fiber and knobs |
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Term
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Definition
| naked icosahedral nucleocapsids, DNA can be incorportated into host DNA, many have oncogenic potential |
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Term
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Definition
| condyloma=genital warts, STD, cervical cancer, Epidermodysplasia verruciformis=warts that turn into squamous carcinoma when exposed to sunlight |
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Term
| Char of Polymaviradae=Polyoma virus (papo. fam)? |
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Definition
| JC and BK form, both infect through RT, BK forms latent infection in kidney, while BK forms latent infection in kidneys, B cells, and monocytic cells, in immunocompromised JC can lead to CNS infection (PML=progressive multifocal leukoencephalopathy) and subsequent demyelination and BK can lead to severe UTIs |
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Term
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Definition
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Term
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Definition
| Tiny, naked, icosahedral, B19 causes erethema infectiosum and possible aplastic crisis in peeps with sickle cell (cuz of drop in heme), and possible hydrops fetalis, adults can get arthritis |
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Term
| Char of Hepadnaviradae (Hep B in partic)? |
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Definition
Icosahedral, enveloped, nicked circ. DNA genome, grown in vitro by transfection, replicates through an RNA intermediate, has RT
replicates in hepatocytes without cytopathic effect, symptoms from cytotoxic response, antigens include HBc(core)-HBe(breakdown prod. of core)-HBs(surface), at risk for Primary Hepatocellular Carcinoma, vaccine from gen. en. HBsAg |
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Term
| DNA viruses most likely to cause cancer? |
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Definition
HPV (16, 18 for cerv.), HHV-8(Kaposi's Sarcoma), EBV (Burkitt's lymphoma) and Hep B
Burkitt's Lymphoma more common in Africa because malaria has immunosuppressive effect |
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