Term
Salmonella
Gram Neg or Pos? |
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Definition
Enterobacteriaceae
Gram Neg. Also, Oxidase Negative. |
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Term
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Definition
| Salmonella ferment glucose not lactose |
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Term
| Three species of Salmonella |
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Definition
| S. Typhi, choleraesuis, and enteritidis (>2k serotypes) |
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Term
| Name all of Salmonella's Exotoxins |
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Definition
| Trick question bitch! Salmonella has no exotoxins! |
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Term
| Salmonella's two Pathogenicity islands (SPIs) |
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Definition
SPI1->invasiveness,
SPI2->survival in macrophages
Type III secretion |
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Term
| Salmonella uptake mechanism |
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Definition
| Salmonella proteins ruffle cell margins by messing w/ actin, >pinocytosis of salmonella into enterocytes |
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Term
| Salmonella Virulence Factors |
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Definition
1. Invasive to epithelium
2. Survive in macrophage
3.Serum resistance proteins
4. LPS
5. Capsule >Vi antigen. (antiphagocytic and serum resistance) |
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Term
| Four presentations of Salmonella |
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Definition
1. Enteric Fever
2. Septicemia
3. Gastroenteritis
4. Asymptomatic |
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Term
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Definition
1. Fever (duh)
2. Constipation >maybe diarrhea
3. Low titer. Rare, but lethal
4. Caused by S. Typhi, Paratyphoid caused by enteritidis strains. |
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Term
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Definition
| Caused by choleraesuis and dublin. Usually w/o GI infection. Suppurative inf. in 10% |
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Term
| Gastroenteritis (enterocolitis |
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Definition
1. Most common Salmonella inf.
2. 6-48 hrs after exposure.
3 NVD, no mucus, blood uncommon. Fever+ Abd cramp+
4. 2days-1week
5. S. enteriditis > frequently infects mesenteric lymph nodes |
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Term
| Salmonella Gastroenteritis Tx |
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Definition
| Abx increase secondary cases. Hydration and electrolyte therapy. |
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Term
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Definition
| secretion of salmonella 1 yr after infection. GB is reservoir. |
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Term
| Shigella causes what major disease |
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Definition
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Term
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Definition
Highly virulent
Non-motile
Not lactose fermenting.
Non gas producing |
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Term
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Definition
Grp A: dysenteriae
Grp B: flexneri
Grp C: boydii
Grp D: sonnei
Shigella Types: Dys Fukkin Bull Son |
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Term
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Definition
| Only Shigella not fermenting manitol. |
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Term
| S. Sonnei special feature |
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Definition
| Only enteric pathogen that ferments lactose. Causes majority of Shigellosis, all others by flexneri. ShigellA>S. dys |
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Term
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Definition
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Term
| primary virulence factor of shigella |
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Definition
1. Invasiveness >actin comet
>ulceration of mucosa
2. Toxin
-Shiga toxinenterotoxic, cytotoxic, neurotoxic. |
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Term
| Virulence of shigella on SPI or plasmid? |
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Definition
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Term
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Definition
| watery diarrhea> fever and diarrhea w/ scant blood, very mucusy and pussy. Shigella does not go past basolateral border of epithelium >> no bacteremia or mesenteric lymph infection. |
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Term
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Definition
| Abx shorten duration to less than 1 week. Chronic uncommon |
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