Term
| What are host defense factors? |
|
Definition
| Enzymes and other agents that occur naturally in saliva and help prevent damage to the teeth and other oral tissues by micro-organisms |
|
|
Term
| What are examples of microbial damage? |
|
Definition
| Dental caries, infections following injury to oral tissue, periodontal disease, autoimmune disease |
|
|
Term
| T/F Oral disease increase with xerostomia. |
|
Definition
|
|
Term
| What is a selective pressure? |
|
Definition
| Host defense blocks the growth of some micro-organisms and permit/favor the growth of others |
|
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Term
|
Definition
| microorganisms that colonize the mouth and grow while attached to the teeth/mouth. Actinomyces and Streptococci |
|
|
Term
| Glycolysis-stimulating factors _ growth of oral microbes but also _ the host by making bacterial metabolism _ acidogenic. |
|
Definition
|
|
Term
| Glyc. Stim factors are _ and _ and produce _ which _. |
|
Definition
| Arginine, urea. NH3, counter acts the acid of the bacteria |
|
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Term
|
Definition
| tertrapeptide (GLY-GLY-LYS-ARG) that is a gly. stim. factor |
|
|
Term
| When Lactic-Acid bacteria metabolize sugars, the pH _. After the sugar is used up and _ is present the pH will _. |
|
Definition
| Drops rapidly, Sialin, slowly rise |
|
|
Term
| What prevents bacteria from binding to orals surfaces and promotes binding to one another? |
|
Definition
| Anitbodies and agglutinating factors |
|
|
Term
|
Definition
| Proteins synthesized by lymphocytes in response to foreign material |
|
|
Term
| What are the 5 classes of antibodies in humans? |
|
Definition
|
|
Term
| What is the main antibody of Blood? Saliva? |
|
Definition
|
|
Term
| T/F Oral bacteria produce IgA protease enzymes that inactivate IgA antibodies. |
|
Definition
|
|
Term
| What are agglutinating factors? |
|
Definition
| Glycoproteins that bind to oral bacteria and interfere with binding to oral surfaces. |
|
|
Term
|
Definition
| A glycoprotein enzyme used specifically to break that chemical bonds in peptidoglycan (structural component in bact. cell walls) |
|
|
Term
| What is the bond hydrolyzed by lysozyme? |
|
Definition
|
|
Term
| How are oral bacteria resistant to lysozyme? |
|
Definition
| They either add groups or layers to peptidoglycans and lysozyme is unable to reach the bond |
|
|
Term
| What is a chelating agent? |
|
Definition
The chelating agent removes a metallic ion from a solid salt and holds it
in solution |
|
|
Term
| What does lactoferrin do? |
|
Definition
| It deprives Iron from the micro-organisms and they can't grow |
|
|
Term
|
Definition
| How lactoferrin is secreted (w/o iron), binds free iron w/in saliva |
|
|
Term
|
Definition
| Inhibit growth of bacteria by interfereing with the uptake and conc. of potassium ions (insterted into cell and make cells leaky for K ions) |
|
|
Term
| Where are the histatins found? |
|
Definition
|
|
Term
| What are the 3 components to the lactoperoxidase antimicrobial system? |
|
Definition
| Lactoperoxidase, hydrogen peroxide, thiocyanate |
|
|
Term
| _ catalyzes the _ of SCN- by _ to produce a weak _ _ with antimicrobial activity. |
|
Definition
| LP, Oxidation, H2O2, oxidizing agent |
|
|
Term
| How does the LPA system inhibit growth? |
|
Definition
| Oxdizing the the sulfhydryl groups (better at low pH) |
|
|
Term
| T/F Lactoperoxidase is bacertiostatic not bactericidal. |
|
Definition
| T! Inhibits growth, doesn't kill |
|
|
Term
| Which portions of an antibody immunoglobulin binds to antigen |
|
Definition
| - the variable regions of the light and heavy chains |
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