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S3 Ross Pharm Skeletal Muscle Relaxants
Turnbull
10
Pharmacology
Professional
11/20/2009

Additional Pharmacology Flashcards

 


 

Cards

Term
A drug which blocks the release of Calcium from the Sarcoplasmic Reticulum.
Definition
Dantrolene
Term
Two long duration non-depolarizing blockers.
Definition

Tubocurarine and Pancuronium.

 

Recall that tubocurarine is contraindicated in people with allergies since in increases histamine levels.

Term
Two intermediate duration non-depolarizing blockers.
Definition

Vecuronium and Atracurium.

 

Recall that Vecuronium is one of the safest drugs to use as a skeletal muscle relaxant.

Term
Two short duration non-depolarizing blockers.
Definition
Mivacurium and Rocuronium.
Term
This skeletal muscle relaxant is contraindicated in burn patients and can cause hyperkalemia.
Definition
Succinyl choline (suxamethonium). This is the ONLY depolarizing blocker.
Term
This drug effects small muscles first, then larger muscles effecting the diaphragm last. When the effect wears off the muscle function comes back in the reverse order. For you computer science geeks: this drug follows LIFO.
Definition
Succinyl choline
Term
This drug forms a byproduct known as laudanosine which has been known to cause seizures.
Definition
Atracurium. Recall that this is an intermediate duration drug.
Term
This drug's MOA is to act as an agonist at GABA-B receptors and acts via a Gi-protein to prevent Ca++ influx.
Definition
Baclofen. This drug is pretty cool because it can potentate morphine analgesia in post-op situations. It has also been used for Spastic Cerebral Palsy
Term
This drug is used as a "rescue" agent for malignant hyperthermia, neuroleptic malignant syndrome, and serotonin syndrome.
Definition
Dantrolene
Term
This drug blocks the release of Ca++ from the sarcoplasmic reticulum. It interferes with ryanodine receptors.
Definition
Dantrolene.
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