Term
| A malignant neoplastic proliferation of hematopoietic stem cells in bone marrow. Neoplastic cells may appear in the PBS as well. |
|
Definition
|
|
Term
| Malignant tumors of lymphoid tissue derived from lymphoid cells. Usually a solid tumor in a lymph node. Might appear in blood. |
|
Definition
|
|
Term
| Polycythemia vera, Essential thrombocythemia, CML are all |
|
Definition
| Myeloproliferative disorders (MPD) |
|
|
Term
| Abnormal proliferation and maturation of WBCs. Leads to pancytopenia. |
|
Definition
| MyeloDISPLASTIC Syndrome (MDS) |
|
|
Term
| Uncontrolled proliferation of histiocytes and dendritic cells. |
|
Definition
|
|
Term
| Patient arrives fatigued and has thrombocytopenia (bleeding problems).PBS shows blasts (immature cells). |
|
Definition
|
|
Term
| Blast count is less than 20%. |
|
Definition
| Chronic leukemia. If Blast count if over 20%, then it could be acute leukemia. |
|
|
Term
|
Definition
|
|
Term
| Myeloid vs. Lymphoid leukemia |
|
Definition
| ALL = kids. AML = 15-30. CLL over 60 |
|
|
Term
| Auer Rods are fused lysosomes see in... |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Hypercellular bone marrow with loss of adipose tissue. |
|
Definition
| Acute leukemia. Can be AML OR ALL |
|
|
Term
|
Definition
| Linear structures in the cytoplasm are Auer Rods. Seen in leukemic cells. |
|
|
Term
| You need to make an AML diagnosis on BM examination. What specific test will you ask for. |
|
Definition
| Myeloperodidase/SBB stain shows auer rods. |
|
|
Term
| All cells are arrested at the myeloblast stage. |
|
Definition
| Acute myelogenous leukemia. |
|
|
Term
|
Definition
| Acute promyelocytic leukemia. t(15,17). Tx is All-trans-retinoic acid. |
|
|
Term
| AML M4 (gum bleeding/hypertrophy) |
|
Definition
| Acute myelomonocytic leukemia |
|
|
Term
| AML M5 (gum bleeding/hypertrophy) |
|
Definition
|
|
Term
|
Definition
| AML diagnosis markers. Also looks for MPO and SBB stain. |
|
|
Term
| Cough, splenomegaly, thrombocytopenia, high WBCs |
|
Definition
|
|
Term
| Faggot cells, DIC, 35-40 years of age |
|
Definition
AML M3: acute promyelocytic leukemia.
LOOKS FOR D-DIMERS INSTEAD OF DIC EXPLICITLY STATED! |
|
|
Term
| Promyelocytes with multiple auer rods |
|
Definition
|
|
Term
| Why does AML M3 pts get DIC? |
|
Definition
| Promyelocytes contain procoagulants which if spilled leads to coagulation. |
|
|
Term
| With t(15/17), why would you see schistocytes? |
|
Definition
| Not sure yet...look it up |
|
|
Term
| Gum infiltration. MPO negative. Non-specific esterase positive. Pt is a kid. CD14 positive. |
|
Definition
| AML M5: acute monocytic leukemia |
|
|
Term
| What better? (AML 8,21) or?........................ |
|
Definition
|
|
Term
| Kids, PAS with pink color, positive for TdT |
|
Definition
|
|
Term
| ALL with more B cell lineage is better or worse than T cell ALL? |
|
Definition
| B cell lineage has a better prognosis. |
|
|
