Term
| what are the three CLASSES of SKELETAL MUSCLE RELAXANTS? |
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Definition
COMPETITIVE BLOCKS-block neuromuscular jxn
DEPOLARIZING BLOCKS-mimic Ach-->fasciculations-->paralysis
ANTISPASMOTICS-centrally and muscle acting |
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Term
| what affect do VOLATILE ANESTHETICS have on MUSCLE RELAXANTS? |
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Definition
| volatile anesthetics ENHANCE the effects of muscle relaxants--> less needed for same result |
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Term
| LONG ACTING competitive muscle relaxants? |
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Definition
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Term
| INTERMEDIATE ACTING competitive muscle relaxants? |
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Definition
|
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Term
| SHORT ACTING competitive muscle relaxants? |
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Definition
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Term
| SHORT acting depolarizing blockers? |
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Definition
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Term
| what are SKELETAL MUSCLE RELAXANTS used for? |
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Definition
-intubation
-stop peristalsis
-electroshock therapy |
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Term
| what substance can be released with SMR? |
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Definition
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Term
| SMR are contraindicated in what conditions? |
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Definition
-myesthenia gravis
-asthma
-plasma cholinesterase deficiencies |
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Term
| what are the SPASMOLYTICS? |
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Definition
-baclofen
-tizanidine
-dantroline
-botulinum toxin |
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Term
|
Definition
-upper motor neuron lesions
-MS
-spinal cord injuries
-cerebral palsy
-post stroke |
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Term
|
Definition
SPASMOLYTIC-->centrally acting
-GABA b receptor agonist
-used in MS
**problem: high doses=DROWSINESS
INTRATHECAL PUMP is implanted for slow release= LESS DROWSINESS** |
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Term
|
Definition
SPASMOLYTIC
-alpha2 receptor agonist
-decreases SYMPATHETIC TONE |
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Term
|
Definition
SPASMOLYTIC-->acts at neuromuscular junction
***antidote for MALIGNANT HYPERTHERMIA*** prevents Ca++ release |
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Term
|
Definition
SPASMOLYTIC-->acts at neuromuscular junction
-blocks Ach release from presynaptic terminal
-used in distal upper limbs/not lower
***BLACK BOX WARNING AGAINST USE IN CEREBRAL PALSY*** |
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Term
|
Definition
DEPOLARIZING agent
-short acting--> first FASCICULATIONS then PARALYSIS
-can cause HYPERKALEMIA
***can cause MALIGNANT HYPERTENSION***--> use DANTROLINE |
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Term
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Definition
| LONG ACTING competitive/non depolarizing agent |
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Term
|
Definition
LONG ACTING competitive/non depolarizing agent
-Nn blocking
-increase HISTAMINE RELEASE |
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Term
|
Definition
| INTERMEDIATE ACTING competitive/non depolarizing agent |
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|
Term
|
Definition
INTERMEDIATE ACTING competitive/non depolarizing agent
-NO HISTAMINE release, NO GANGLIONIC block |
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|
Term
|
Definition
SHORT ACTING competitive/non depolarizing agent
-increases HISTAMINE release
***cleared by plasma CHOLINESTERASES*** |
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