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S3.M3.Pharm 2
Bipolar-Lithium
9
Pharmacology
Professional
08/09/2010

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Cards

Term
uses of LITHIUM?
Definition
-1st line treatment of BIPOLAR disorder
-PROPHYLACTIC treatment of BIPOLAR and MANIC disorders
-SCHIZOEFFECTIVE disorder in combo with antipsychotics
Term
what is MANIA?
Definition
-Mentally and physically HYPERACTIVE
-elevated mood
-Disorganized behavior
-incessant talking and flight of ideas
-Speech is pressured--> rhymes and puns
-GRANDIOSE DELUSIONS --> feelings of self importance
Term
mania with a contrary MOOD SWING is known as what?
Definition
bipolar disorder
Term
what is LITHIUM's relationship with Na+? effects on neural tissue?
Definition
-Li+ substitutes for Na+ in all Na+ compartments, Na+ is lost , and lithium retained
-Lithium is especially toxic to nervous tissue
-very narrow THERAPEUTIC INDEX
Term
what must every patient have done prior to beginning lithium therapy? testing what?
Definition
pretreatment WORKUP
-tests renal function-> excreted by kidney
-ECG--> can cause cardiac problems
-CBC--> can increase WBC and PLATELET levels
Term
does LITHIUM act immediately? what is often given conjointly?
Definition
doesn't work immediately, therefore ANTIPSYCHOTICS (OLANZAPINE) are often given to tide patients over until effective
Term
lithium MOA?
Definition
INHIBITS adenylyl cyclase--> decreases cAMP
Term
**common ADVERSE SIDE EFFECTS** KNOW THESE
Definition
-fine hand TREMOR
-thirst and POLYURIA
-***nephrogenic DIABETES INSIPIDUS
-weight gain
-benign diffuse GOITRE
-worsening SKIN PROBLEMS

**CARDIAC EFFECTS and interstitial NEPHRITIS
Term
what drug is often used now in place of LITHIUM?
Definition
VALPROATE
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