| Term 
 
        | Ergotamine Dihydroergotamine
 |  | Definition 
 
        | 5HT AGONIST -analgesic-->migraine pain ONLY--> 1ST sign of attack otherwise ineffective
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5HT AGONIST -anxiolytic to treat generalized anxiety disorder
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | used for migraine and cluster headaches |  | 
        |  | 
        
        | Term 
 
        | Phenothiazines and butyrophenones |  | Definition 
 
        | 5HT ANTAGONIST-->ANTIPSYCHOTICS treatment of schizophrenia and mania
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Treatment of primary pulmonary hypertension |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | Treatment of open angle glaucoma |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | H1 antagonist -potent local anesthetic
 -prevent motion sickness
 -used in PARKINSONS**
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -used for erectile dysfunction -treats PATENT DUCTUS ARTERIOSUS
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | H2 ANTAGONIST -Blocks dihydrotestosterone binding to androgen receptor--> gynecomastia, loss of libido, impotence
 -inhibits metabolism of estradiol
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -causes smooth muscle contraction in vagina -ripens cervix to induce labor
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -induce early abortion -Treatment of NSAID-induced peptic ulcers
 **given orally or vaginally
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5HT AGONIST -Postpartum bleeding-->placental delivery
 -Diagnosis of variant angina-->coronary angiography
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -Induction of 2nd trimester abortion -controls postpartum hemorrhage
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 2nd generation H1 receptor antagonist--> very effective in treatment of ALLERGIES if taken before exposure **NO CNS, NO DROWSINESS
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5‐HT Antagonists -blocks serotonin receptors
 -smooth muscle manifestations of carcinoid tumor and cold-induced urticaria
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | o Reduce the degranulation of mast cells caused by immunologic triggering-->reduce the release of histamine |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | o Reduce the degranulation of mast cells caused by immunologic triggering-->reduce the release of histamine |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5‐HT Antagonists -prevent the nausea and vomiting associated with surgery and cancer chemotherapy
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | -alpha-receptor blocking effects -potent local anesthetic
 -prevent motion sickness-->SEDATIVE
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5‐HT Antagonists -Alters bleeding time and reduces thromboxane formation by altering platelet function
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | 5‐HT Antagonists, ALPHA Antagonist -manage pheochromocytoma
 |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | H1 antagonists (long acting) – Prevent motion sickness |  | 
        |  | 
        
        | Term 
 | Definition 
 
        | H1 antagonist (Dramamine) – Treatment of motion sickness
 |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 | Definition 
 
        | H2 ANTAGONIST high bioavailability
 |  | 
        |  | 
        
        | Term 
 | Definition 
 | 
        |  | 
        
        | Term 
 
        | ***ANTACIDS reduce the absorption of H2 ANTAGONISTS |  | Definition 
 | 
        |  |