Term
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Definition
| SMOOTH MUSCLE, endothelium-->Activates the IP3/DAG |
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Term
|
Definition
| GASTRIC MUCOSA, cardiac muscle, mast cells |
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Term
| what CELL TYPES are involved in the TRIPLE RESPONSE? |
|
Definition
-Microcirculation vessel smooth muscle cells
-Capillary/venular endothelium
-Sensory neurons |
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Term
| clinical uses/general effects of H1 ANTAGONISTS? |
|
Definition
TRADITIONAL ANTIHISTAMINES--> prevention, treatment of allergic rxn, motion sickness, mastocytosis:
-Strong inhibition of edema formation and itching
-Partial inhibition of histamine-induced hypotension
-Strong antinausea and antiemetic actions
-Strong inhibition of bronchiolar and GI smooth muscle contraction |
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Term
| clinical uses/general effects of H2 ANTAGONISTS? |
|
Definition
Used to treat peptic ulcer disease--> GERD, peptic ulcer disease:
-Suppresses basal and meal-stimulated gastric acid secretion
-Reduces the volume of gastric secretion and [pepsin]
-Strongly reduces histamine-stimulated gastric acid secretion |
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