Term
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Definition
| Unwanted, non-deleterious effects appearing after administration of standard therapeutic doses and RELATED TO THE PHARMACOLOGICAL PROPERTIES of the drug |
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Term
| what are some FEATURES of drug SIDE EFFECTS? |
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Definition
-found with most drugs, but patients are variable, generally not serious
-dose dependent and related to drug properties
-mechanism often drug receptor interaction
-switching drugs or changing dose is recommended |
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Term
| what is OVERDOSE TOXICITY? |
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Definition
| Unwanted effects appearing after administration of doses higher than the therapeutic ones |
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Term
| what are the FEATURES of OVERDOSE TOXICITY? |
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Definition
-all drugs, all subjects (if dose is high enough)
-danger can be high depending on drug and dose
-drug receptor interaction
-treated with antagonist or lower dosage |
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Term
| what is a DRUG IDIOSYNCRACY? |
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Definition
| A genetically determined, abnormal reactivity to a drug |
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Term
| FEATURES of DRUG IDIOSYNCRACY? |
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Definition
-low incidence, depending on person and drug
-can be serious depending on drug and dose
-stop drug and use antagonist if available |
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Term
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Definition
| An unwanted drug effect resulting from previous sensitization to the same drug or a closely related one |
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Term
| FEATURES of a DRUG ALLERGY? |
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Definition
-low incidence despite possibility in many drugs
-can be very serious
-unlike others which are drug receptor dependent, this is IMMUNOLOGICAL in mechanism |
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Term
| what are the 4 types of DRUG ALLERGIES? |
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Definition
TYPE I - immediate rxns--> via IgE of mast cells and basophils
TYPE II- antibody dependent cytotoxicity-->drug binds to self cell eliciting immunological response
TYPE III-immune complex-mediated reaction
Type IV-delayed or cell-mediated reaction (contact dermatitis is most common) |
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