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S3.M1.Pharm8
ANS Pharm
25
Pharmacology
Professional
05/25/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
what receptors does NE work on?
Definition
alpha 1,2 and beta 1
adrenergic
Term
what receptors does Epi work on?
Definition
alpha 1,2 and beta 1,2
adrenergic
Term
is the ratio of PRE to POSTGANGLIONIC fibers higher in sympathetic or parasympathetic nerves
Definition
higher in SYMPATHETIC (1:20) vs.
PARASYMPATHETIC (1:3)
Term
what GANGLIA are involved in PARASYMPATHETIC synapsing in the BRAIN?
Definition
Ciliar
Submandibular
Pterygopalatine
Otic
Term
***what SYMPATHETIC controlled muscle is involved in DILATION of the pupil? what receptor is stimulated?***
Definition
radial muscle, alpha1
Term
in the HEART, innervation from the ATRIA/VENT comes mostly from the SYMP/PARA
Definition
ATRIA-PARASYMPATHETIC
VENTRICLES-SYMPATHETIC
Term
what is the main CENTER OF AUTONOMIC INTEGRATION?
Definition
solitary tract nucleus
Term
where is the origination of PREGANGLIONIC PARASYMPATHETIC NEURONS?
Definition
-CN III, VII, IX, X nuclei
-S2,3,4
Term
what breaks down NE and Epi?
Definition
NE- MAO, COMT
epi-COMT
Term
ALPHA 1: g protein coupling and location
Definition
Gq-->Vascular smooth muscle, visceral smooth muscle (mainly sphincters), radial muscle of iris
Term
ALPHA 2: g protein coupling and location
Definition
Gi & G0-->Some presynaptic terminals, platelet aggregation
Term
BETA 1: g protein coupling and location
Definition
Gs-->Myocardium, juxtaglomerular cells
Term
BETA 2: g protein coupling and location
Definition
Gs-->Visceral smooth muscle, vascular smooth muscle, liver
Term
BETA 3: g protein coupling and location
Definition
Gs-->Adipocytes
Term
D-1: g protein coupling and location
Definition
Vascular smooth muscle (renal and mesenteric vascular beds)
Term
what NEUROTRANSMITTER is secreted at the sweat glands? what ANS division is responsible for this?
Definition
ACh--> postganglionic SYMPATHETIC
Term
only PARASYMPATHETIC NERVE that originates from the head, but performs functions below the neck?
Definition
vagus
Term
how do BETA BLOCKERS mask/complicate the effects of hypoglycemia from a diabetic patient on insulin therapy?
Definition
1- they further decrease plasma GLUCOSE levels by decreasing gluconeogenesis and glycogenolysis
2-usually hypoglycemic patients exhibit tachycardia which is also suppressed by beta blockers-->masking effect
Term
what receptors have a strong effect on the KIDNEY and renin secretion?
Definition
beta 1 --> beta 1 specific blockers decrease renin/angiotensin/aldosterone
Term
what drug is used to delay premature labor in pregnant women? what receptor does his work through?
Definition
RITODRINE beta 2 receptors cause relaxation of the uterus
Term
what receptors cause contraction in the pregnant uterus?
Definition
alpha 1
Term
why are beta 2 agonists potentially dangerous for diabetic patients?
Definition
they raise plasma glucose levels
Term
what is an AUTORECEPTOR? what is a HETERORECEPTOR?
Definition
AUTORECEPTORS--> on presynaptic terminals, bind NT from the SAME presynaptic nerve-->modulates the release of same NT from same presynaptic nerve

HETERORECEPTORS --> on presynaptic terminals, bind NT from ANOTHER presynaptic nerve --> modulates NT secretion of the presynaptic nerve on which the receptor is found *usually INHIBITORY
Term
what is an example of PRESYNAPTIC REGULATION between sympathetic and parasympathetic nerves?
Definition
NT bind HETERORECEPTORS on presynaptic terminals and INHIBIT NT secretion:

PARASYMPATHETIC secretes ACh which binds M2 receptors
SYMPATHETIC secrets NE which binds alpha 2 receptors
Term
Epi autoreceptors are what type of receptor
Definition
beta 2
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