Term
| what receptors does NE work on? |
|
Definition
alpha 1,2 and beta 1
adrenergic |
|
|
Term
| what receptors does Epi work on? |
|
Definition
alpha 1,2 and beta 1,2
adrenergic |
|
|
Term
| is the ratio of PRE to POSTGANGLIONIC fibers higher in sympathetic or parasympathetic nerves |
|
Definition
higher in SYMPATHETIC (1:20) vs.
PARASYMPATHETIC (1:3) |
|
|
Term
| what GANGLIA are involved in PARASYMPATHETIC synapsing in the BRAIN? |
|
Definition
Ciliar
Submandibular
Pterygopalatine
Otic |
|
|
Term
| ***what SYMPATHETIC controlled muscle is involved in DILATION of the pupil? what receptor is stimulated?*** |
|
Definition
|
|
Term
| in the HEART, innervation from the ATRIA/VENT comes mostly from the SYMP/PARA |
|
Definition
ATRIA-PARASYMPATHETIC
VENTRICLES-SYMPATHETIC |
|
|
Term
| what is the main CENTER OF AUTONOMIC INTEGRATION? |
|
Definition
|
|
Term
| where is the origination of PREGANGLIONIC PARASYMPATHETIC NEURONS? |
|
Definition
-CN III, VII, IX, X nuclei
-S2,3,4 |
|
|
Term
| what breaks down NE and Epi? |
|
Definition
|
|
Term
| ALPHA 1: g protein coupling and location |
|
Definition
| Gq-->Vascular smooth muscle, visceral smooth muscle (mainly sphincters), radial muscle of iris |
|
|
Term
| ALPHA 2: g protein coupling and location |
|
Definition
| Gi & G0-->Some presynaptic terminals, platelet aggregation |
|
|
Term
| BETA 1: g protein coupling and location |
|
Definition
| Gs-->Myocardium, juxtaglomerular cells |
|
|
Term
| BETA 2: g protein coupling and location |
|
Definition
| Gs-->Visceral smooth muscle, vascular smooth muscle, liver |
|
|
Term
| BETA 3: g protein coupling and location |
|
Definition
|
|
Term
| D-1: g protein coupling and location |
|
Definition
| Vascular smooth muscle (renal and mesenteric vascular beds) |
|
|
Term
| what NEUROTRANSMITTER is secreted at the sweat glands? what ANS division is responsible for this? |
|
Definition
| ACh--> postganglionic SYMPATHETIC |
|
|
Term
| only PARASYMPATHETIC NERVE that originates from the head, but performs functions below the neck? |
|
Definition
|
|
Term
| how do BETA BLOCKERS mask/complicate the effects of hypoglycemia from a diabetic patient on insulin therapy? |
|
Definition
1- they further decrease plasma GLUCOSE levels by decreasing gluconeogenesis and glycogenolysis
2-usually hypoglycemic patients exhibit tachycardia which is also suppressed by beta blockers-->masking effect |
|
|
Term
| what receptors have a strong effect on the KIDNEY and renin secretion? |
|
Definition
| beta 1 --> beta 1 specific blockers decrease renin/angiotensin/aldosterone |
|
|
Term
| what drug is used to delay premature labor in pregnant women? what receptor does his work through? |
|
Definition
| RITODRINE beta 2 receptors cause relaxation of the uterus |
|
|
Term
| what receptors cause contraction in the pregnant uterus? |
|
Definition
|
|
Term
| why are beta 2 agonists potentially dangerous for diabetic patients? |
|
Definition
| they raise plasma glucose levels |
|
|
Term
| what is an AUTORECEPTOR? what is a HETERORECEPTOR? |
|
Definition
AUTORECEPTORS--> on presynaptic terminals, bind NT from the SAME presynaptic nerve-->modulates the release of same NT from same presynaptic nerve
HETERORECEPTORS --> on presynaptic terminals, bind NT from ANOTHER presynaptic nerve --> modulates NT secretion of the presynaptic nerve on which the receptor is found *usually INHIBITORY |
|
|
Term
| what is an example of PRESYNAPTIC REGULATION between sympathetic and parasympathetic nerves? |
|
Definition
NT bind HETERORECEPTORS on presynaptic terminals and INHIBIT NT secretion:
PARASYMPATHETIC secretes ACh which binds M2 receptors
SYMPATHETIC secrets NE which binds alpha 2 receptors |
|
|
Term
| Epi autoreceptors are what type of receptor |
|
Definition
|
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