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S3.M1.Pharm1
General Principles
8
Pharmacology
Professional
05/10/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
what three processes are associated with PHARMACOKINETICS?
Definition
The part of pharmacology dealing with the study of the temporal pattern of the processes of
absorption, distribution, elimination
of drugs
Term
what is ABSORPTION?
Definition
crossing of drug from external environment to the systemic circulation
Term
what is BIOAVAILABILITY?
Definition
the fraction (F) of a drug dose reaching unchanged the systemic circulation when administered by any route
Term
what factors affect BIOAVAILABILITY?
Definition
a) the route of administration
b) all those factors acting on absorption
Term
BIOAVAILABILITY is a CONSTANT, it is not dependent on dose - it is a fraction
Definition
Term
All drugs given by oral route are absorbed mainly by what?
Definition
the small intestine
Term
Vd of a drug is constant-is NOT DEPENDENT ON THE DOSE!!
Definition
Term
what are examples of PHASE I biotransformation rxns?
Definition
phase 1 - oxidation, reduction, hydrolyses
phase 2 - conjugation
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