Term
| what three processes are associated with PHARMACOKINETICS? |
|
Definition
The part of pharmacology dealing with the study of the temporal pattern of the processes of
absorption, distribution, elimination
of drugs |
|
|
Term
|
Definition
| crossing of drug from external environment to the systemic circulation |
|
|
Term
|
Definition
| the fraction (F) of a drug dose reaching unchanged the systemic circulation when administered by any route |
|
|
Term
| what factors affect BIOAVAILABILITY? |
|
Definition
a) the route of administration
b) all those factors acting on absorption |
|
|
Term
| BIOAVAILABILITY is a CONSTANT, it is not dependent on dose - it is a fraction |
|
Definition
|
|
Term
| All drugs given by oral route are absorbed mainly by what? |
|
Definition
|
|
Term
| Vd of a drug is constant-is NOT DEPENDENT ON THE DOSE!! |
|
Definition
|
|
Term
| what are examples of PHASE I biotransformation rxns? |
|
Definition
phase 1 - oxidation, reduction, hydrolyses
phase 2 - conjugation |
|
|
