Term
| Besides antiviral drugs what is needed to recover from a viral infection. |
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Definition
| A proper host immune response. |
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Term
| This is the DOC for HSV encephalitis. |
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Definition
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Term
| These 2 (or 4) drugs are activated by viral thymidine kinase. |
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Definition
| Valacyclovir/Acyclovir. Valganciclovir/Ganciclovir |
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Term
| What is the MOA for Ganiclovir and Acyclovir? |
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Definition
| Inhibits viral DNA-polymerase |
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Term
| Between Acyclovir and Ganiclovir, which drug does NOT cause nephrotoxicity? |
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Definition
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Term
| This drug is only available in a topical solution. |
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Definition
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Term
| The DOC for HSV 1/2 aka Kerato-conjunctivitis. |
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Definition
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Term
| The DOC for Cytomegalovirus |
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Definition
| Valganciclovir/Ganciclovir |
|
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Term
| This is a myelosupressive drive which works by inhibiting viral DNA polymerase. |
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Definition
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Term
| The next choice drug if you find resistance to Valganciclovir. What is the major toxicity of this drug? |
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Definition
| Cidoforvir. It has notable nephrotoxicity which can be reduced by co-administering Probenecid to reduce tubular secretion. This WILL increase the halfife of Cidoforvir. |
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Term
| If you see resistance to Cidoforvir, what is the next drug you would use? |
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Definition
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Term
| One of the DOC for HIV. It directly inhibits viral DNA pol. AND reverse transcriptase. |
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Definition
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Term
| Foscarnet is an interesting drug for several reasons. It does not require phosphorylation for activity and causes some adverse effects including Nephrotoxicity and Neurotoxicity. What is the other toxicity? What does this lead to? |
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Definition
| Hypocalcemia. It chelates calcium. Up to 30% of it will actually deposit in the bones. This in turn leads to a longer half life. |
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Term
| Use this drug when you see resistance to all other antiviral drugs. |
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Definition
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Term
| This drug is an anti-sense gene therapy and is available only through intervitreal injection due to severe systemic toxiciy effects. |
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Definition
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Term
| These two drugs only battle influenze Type A. What are the two drugs and why can they only fight against Type A? |
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Definition
| Amantadine and Rimantadine. They work by inhibiting viral uncoating. |
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Term
| What is the MOA of Anatadine and Rimantadine? |
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Definition
| Inhibition of viral M2 ion channels. This increases the pH of the endosome which inhibits uncoating. |
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Term
| Amantadine and Rimantadine have the "Twin Sibbling Complex" and try be different from each other in any way possible. To most people they look exactly the same. You, however, know the secret to tell them apart... |
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Definition
| Amantadine can cross the BBB. |
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Term
| These two drugs are Neuraminidase A and B inhibitors. |
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Definition
| Oseltamivir (Tamiflu) and Zanamirvir. They prevent the release of new virions. |
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Term
This drug is orally administered, has a lengthened halflife when co-administered with Probenecid, and can cause nause and abdominal discomfort.
If thats not enough information, it has also been used in obscence amounts over the past several months (2009) |
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Definition
| Oseltamivir. It's sibbling Zanamirvir is administered via powered intranasally and can cause bronchospasms (good luck prescribing it) |
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Term
| The DOC for Lassa Fever. Also for RSV or pediatric pneumonia. |
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Definition
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Term
| What drugs are administered at concurrently with Ribavirin for Hep C. |
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Definition
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Term
| This drug is used for Respiratory Sysctial Viruses and is very teratogenic. |
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Definition
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Term
| A MAB against epitope in A antigen site of F glycoprotein on the surface of RSV. It is given SQ. |
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Definition
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Term
| What induces INF-alpha, beta, and gamma? |
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Definition
Alpha - (leukocyte) - induced by viruses
Beta - (fibroblast) - induced by viruses
Gamma - (immune) - induced by antigens |
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Term
| What induce protein kinase, oligo-adenylate synthase, and phosphodiesterases to inhibit translation? |
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Definition
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Term
| Why would you want to add PolyEthylene Glycol to interferons? |
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Definition
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Term
| List three major adverse effects of interferons. |
|
Definition
1. Acute flu-like syndrome
2. Myelosuppression (recall ganciclovir also does this)
3. Neurotoxicity |
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Term
| A well-tolerated non-interferon drug used to treat hepatic viral infections. What are two other drugs given if there is resistant to the former drug? |
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Definition
| Lamivudine is lovley. Adefovir and Entecavir, not so much. |
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Term
| Name two Nucleoside Reverse Transcriptase Inhibitors that are Thymidine analogs. |
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Definition
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Term
| Name two NRTI's that are cytosine analogs. |
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Definition
| Lamivudine and Emtricitabine |
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Term
| This drug is a guanoside analog that can produce a hypersensitivity reaction in 8% of the population. |
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Definition
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Term
| This drug is the only nucleoTIDE analog. |
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Definition
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Term
| A deoxyadenoside analog that can cause pancreatitis and peripheral neuropathy. |
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Definition
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|
Term
Three NRTI's that are active against Hepatitis B.
"Please don't LET it be Hep B!!" |
|
Definition
Lamivudine
Emtricitabine
Tenofovir |
|
|
Term
| What drug should you not use concurrently with Zidovudine? |
|
Definition
| Stavudine. They are both thymidine analogs. |
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Term
| These HIV drugs are activated by phosphorylation, where once activated will COMPETITIVELY inhibit reverse transcriptase. |
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Definition
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Term
| What's so special about NED? |
|
Definition
NED is a non-competative inhibitor of reverse transcriptase. He is only effective against HIV-1.
NED = Nevirapine, efavirenze, delavirdine. |
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Term
| Out of all the NNRTI's, which one is (completely) an inhibitor? |
|
Definition
| Delavirdine. Recall that NED will give you a rash. |
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Term
| Which NNRTI produces psychosis and is contraindicated in preggos? |
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Definition
| Efavirenz produces CNS effects and is a class D drug, thus should not be used during pregnancy. |
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Term
| You've broken into a pharmacy after a heavy bout of drinking. You're looking for HIV drugs. Specifically protease inhibitors but you can't quite remember the drug names. But you do remember the suffix... |
|
Definition
-navir
Saquinavir, ritonavir, lopinavir, indinavir, atazanavir |
|
|
Term
| This is the only protease inhibitor that ALSO inhibits CYP-450. |
|
Definition
| Ritonavir. Recall that this drug makes your mouth tingle. If you're in med school, thats called Circumaural paresthesia. |
|
|
Term
| What is the MOA of protease inhibitors? |
|
Definition
| They interfere with post-translational processing of precursors. This leads to the production of immature HIV copies. |
|
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Term
| Which protease inhibitor can have the adverse effects of nephrolithiasis and hyperbilirubinemia? |
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Definition
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|
Term
| All the protease inhibitors cause Lipodystrophy leading to metabolic syndrome except for... |
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Definition
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|
Term
| What is the MOA of Zitevir? |
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Definition
| It is an integrase inhibitor which prevents HIV from infecting new cells. |
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Term
The drug behind door X has the following properties. If you can name it, you win a boost in self-esteem.
Can cross BBB.
Can prevent vertical transmission.
Undergoes Hepatic Glucuronidation.
Myelosuppressive, causes Myopathy and Hepatotoxicity. |
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Definition
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