Term
| Name a group of organisms that are very similar to gram negatives with a weakly endotoxic LPS, have no PG and cannot produce several aminio acids and 3 out of the 4 nucleoside triphosphates. |
|
Definition
| Chlamydiaceae. They are obligate intracellular pathogens. So they need to grow and multiply within eukaryotic cells. |
|
|
Term
| Which form of Chlamydiae can be found on clothing? |
|
Definition
| The Elementary Body is metabolically inactive and is an extracellular spore-like structure which is infective. |
|
|
Term
| Where do elementary bodies attach to cells and how do they enter cells? |
|
Definition
| EBs attach to the apical surfaces of epithelial cells and enter via Receptor-mediated endocytosis. |
|
|
Term
| How do EB's avoid lysosomal fusion? |
|
Definition
| By modifying the early endosomal membrane to exit the endosomal pathway. |
|
|
Term
| Out of C. trachomatis, pneumonia, psittaci, which one(s) have only one inclusion? |
|
Definition
| C. trachomatis has all the EB-containing endosomes to fuse to form ONE inclusion. The others form multiple inclusions. |
|
|
Term
| What is the dormant state of Reticulate Bodies called? |
|
Definition
|
|
Term
| You randomly wake up in the streets of Kolkata. You don't remember your name but you know 9 languages and 5 forms of martial arts. Your primary concern (besides remembering your name) is what three forms of C. Trachomatis? |
|
Definition
C. Trachomatis A,B,Ba,and C are found in overcrowded areas (usually India and Africa).
Recall that this only has ONE inclusion body. |
|
|
Term
| This is a card you can probably skip...Where is C. pecorum found and what can it cause? |
|
Definition
| It is found in pigs, sheep, cattle, and koalas. It can cause sporadic encephalitis, polyarthritis, pneumonia, and conjunctivitis. |
|
|
Term
| What C. Trachomatis serovars are responsible for venereal disease, conjunctivitis and pneumonitis? |
|
Definition
| Serovars D-K cause disease of the eyes and genitals. |
|
|
Term
| You are the newest medical officer aboard the Starship Enterprise. A patient is brought to you and your Triquarter reveals serovars of LGV1, LGV2, and LGV3. What disorder are you thinking? |
|
Definition
| Lymphogranuloma venereum. |
|
|
Term
This obligate intracellular organism infects nonciliated, columnar, and transitional epithelial cells and is found in several mucous membranes. It tends to destroy cells directly during replication or due to host inflammatory response.
More to note, an infection of this organism does not provide any long-lasting immunity. What is the bug? |
|
Definition
|
|
Term
| The world's leading cause of preventable blindness is due to... |
|
Definition
| Trachoma. It is transmitted eye-to-eye by droplets, hands, clothing or flies. |
|
|
Term
| Lets play some random word association: Homosexual men, primary painless lesion, proximal lymph node swelling. Whats the disease? |
|
Definition
|
|
Term
| What lab markers do you expect to see for the diagnosis of LGV. Looking for Cytology, Culture, Antigen detection, Nucleic acid probes, and Serology. |
|
Definition
Cytology - Inclusions.
Culture - HeLa, McCoy, high specificity but low sensitivity.
Antigen Detection - eh, not really important.
Nucleic Acid Probes - THIS IS WHAT YOU USE FOR VD!!!
They PROBE your urethra for sample collection.
Serology - looking for IgM in infants or LGV at any age. |
|
|
Term
| Like N.meningitis, this microbe is found in college campuses and military bases. It causes Walking Pneumonia. Interestingly it has been known to cause arteriosclerosis. |
|
Definition
| Chlamydia pneumoniae. Diagnosis is via serology since culture is difficult. Treatment is via Doxyclcine. |
|
|
Term
| A little known fact about Capt. Jack Sparrow is that he is a huge germaphobe. This is exactly why he doesn't have a parrot. What disease is he most likely afraid of? |
|
Definition
| Chlamydia psittaci. Contracted from inhalation of dried bird feces or feather dust. |
|
|
Term
| What is the gram status of Rickettsia , Ehrlichia, Anaplasma, and Coxiella? Which is the only one that is NOT transmitted by arthropods? |
|
Definition
| They are all considered to be gram (-) even though they stain poorly. Coxiella is NOT transmitted by arthropod. |
|
|
Term
| Name the Host target Cell and Cellular location for: Rickettsia |
|
Definition
Host Target Cell: Endothelium
Cellular Location: Cytosol and nucleus |
|
|
Term
| Name the Host target Cell and Cellular location for: Coxiella |
|
Definition
Host Target Cell: Macrophage
Cellular Location: Cytosol and nucleus |
|
|
Term
| Name the Host target Cell and Cellular location for: Ehrlichia |
|
Definition
Host target Cell: Monocytes
Cellular Location: Cytoplasmic endosomal vacuole |
|
|
Term
| Name the Host target Cell and Cellular location for: Anaplasma |
|
Definition
Host Target Cell: Granulocytes
Cellular Location: Cytoplasmic endosomal vacuole |
|
|
