Term
| Osteoarthritis men vs. women |
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Definition
men= hips
women=hands, knees |
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|
Term
| gene involved in pathogenesis of OA |
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Definition
| WNT, prostaglandin metabolism |
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Term
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Definition
1. chondrocyte injury (aging, biochemical factors)
2. early OA, chondrocyte proliferation and secretion of inflammatory mediators
3. late OA, repeptitive injury and chronic inflammation lead to chondrocyte drop out, loss of cartilage and subchondral bone changes |
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Term
| granular soft articular surface |
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Definition
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Term
|
Definition
| pieces of cartilage sloughed off in OA that fall into the joint |
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Term
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Definition
| OA; exposed subchondral bone plate becomes new articular surface, friction with opposing degenerated articular surface smooth and burnishes exposed bone |
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Term
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Definition
| due to small fractures in articular bone (in OA) that allow synovial fluid to be forced into the subchondral regions. |
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Term
| Mushroom shaped osteophytes |
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Definition
| OA- boney outgrowths that develop at the margins of the articular surface and are capped by fibrocartilage and hylaine cartilage that gradually ossify |
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Term
| deep achey pain, worsens with ue, morning stiffness, crepitus and limitation of range of motion; lumbar nerve compression, radicular pain, muscle spasms, atrophy, neuro deficits |
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Definition
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|
Term
| typical joints involved in OA |
|
Definition
| hips, knees, lower lumbar, cervical proximal and distal IP joints |
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|
Term
| chronic systemic inflammatory disorder affecting many tissues and organs |
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Definition
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|
Term
| increased vascularity due to vasodilation and angiogenesis with superficial hemosiderin deposits |
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Definition
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|
Term
| destroyed cartilage, pannus bridges with apposing bones and ossifies |
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Definition
| fibrous ankylosis-->bony ankylosis |
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|
Term
| inflammation in tendons, ligaments and skeletal muscle frequently accompany this type of arthritis |
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Definition
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|
Term
| where do you find RA nodules? |
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Definition
| lungs, spleen, pericardium, myocardium, heart valves, aorta, viscera |
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Term
| condition in which segments of small arteries such as vasa nervorum and digital arteries are obstructed by an obliterating endarteritis resulting in peripheral neuropathy, ulcers and gangrene |
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Definition
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|
Term
|
Definition
| HLA-DRB1, PTPN22 (protein tyrosine phosphotase participating in activation and control of inflammatory cells |
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|
Term
| mediator or cytokine antagonist which can relieve RA swelling and pain |
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Definition
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|
Term
|
Definition
| symmetrical and small joints before larger ones; hands MP PIP first; then wrist, ankles, elbows, knees |
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|
Term
| swollen, warm, painful, stiff on arising or following inactivity |
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Definition
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|
Term
|
Definition
1. morning stiffness
2. arthritis in three or more joints
3. arthritis of hand
4. symmetrical
5. RA nodules
6. serum RA factor
7. radiographic changes |
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|
Term
| RA patients treated with TNF antagonist are susceptible to? |
|
Definition
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|
Term
|
Definition
1.) oligoarthritis more common
2.) systemic disease more frequent
3.) large joints>small joints
4.) RA nodules and RA factor ABSENT
5.) ANA + |
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|
Term
| JIA oligoarthritis variant |
|
Definition
| four or less joints, absence of psoriasis and HLA-B27 geneotype; younger than 6 years old, iridocylitis and positive ANA |
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|
Term
| JIA enthesitis related arthritis |
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Definition
| children younger than 6, HLA-B27+; tendoligamentous insertion sites and joints of lower extremeties |
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|
Term
| chronic synovitis which causes destruction of articular cartilage and bony ankylosis, especially of sacroiliac and apophyseal joints |
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Definition
| Rheumatoid spondylitis and Marie-Strumpell disease |
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|
Term
| inflammation of tendinoligamentous insertion sites which eventuates their ossification producing squaring and fusion of vertebral bodies resulting in severe spinal immobility |
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Definition
| anakylosing spondyloarthritis, rheumatoid spondylitis, Marie-Strumpell disease (all the same disease) |
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Term
| reactive arthritis defined by arthritis, non-gonococcal urethritis or cervicitis and conjunctivitis |
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Definition
| reiter syndrome (men in their 20-30s, also prevalent in HIV+ patients) |
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Term
| autoimmune reaction initiated by prior infection of GI with shigella, salmonella, yersinia, campylobacter and chlamydia (genitalurinary) |
|
Definition
| reiter syndrome; also could be enteritis associated arthritis (not necessarily autoimmune) |
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|
Term
| joints affected in Reiter syndrome |
|
Definition
| joint stiffness and low back pain (early symptoms); ankles, knees, and feet in an asymetrical pattern |
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|
Term
| chronic inflammatory arthropathy affecting peripheral and axial joints and entheses and is associated with psoriasis |
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Definition
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|
Term
|
Definition
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|
Term
| Most common bacteria in bacterial arthritis |
|
Definition
| gonococcus, staph, strep, Haemophilus influenzae, E coli, salmonella, psudomonas, |
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|
Term
| diseases with synovial pannus (4) |
|
Definition
RA
tuberculous arthritis
lyme arthritis
really bad cases of gout can progress to this... |
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|
Term
|
Definition
| overproduction of uric acid with increased urinary excretion; increased nucleic acid turnover (leukemias), inborn errors of metabolist (complete HGPRT deficiency), reduced excretion of uric acid with normal production, chronic renal disease |
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|
Term
|
Definition
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|
Term
|
Definition
articular cartilage
periarticular ligaments
tendons
soft tissue-->olecronon bursa, patellar bursae
achilles tendon
earlobes
kidneys, nasal cartilages, skin of fingertips, palms, soles, |
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|
Term
|
Definition
| psuedo gout; autosomal dominant form |
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|
Term
|
Definition
| articular matrix, menisci, IV discs, |
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