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Rheumatoid Arthritis
Therapy Final
15
Pharmacology
Professional
12/08/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
hydrochloroquine
Definition
can take up to a year to see clinical effects, eye exams to check for retinal damage
Term
sulfasalazine
Definition
urine discoloration
Term
methotrexate
Definition
inhibits dihydrofolate reductase, increasing adenosine which inhibits lymphocyte proliferation; supplement with folate
Term
glucocordicoids
Definition
symptomatic relief, may be used intraarticularly
Term
leflunomide (Arava)
Definition
can be used with NSAID or ASA and low dose corticoids; inhibits Cox2 and some leukotrienes and blocks pyrimidine synthesis/ tyrkinase
Term
pregnancy category X
Definition
leflunomide, methotrexate
Term
entanercept
Definition
human TNFalpha receptor Fc fusion protein,SQ, immunosupression and injection site reactions
Term
infliximab
Definition
chimaric mouse mAB specific for TNF, IV infusion, can develop antinuclear Abs
Term
adalimumab (Humira)
Definition
human mAB specific for TNF, SQ, think immunosuppression, black box TB infection relapse
Term
cimzia (certolizumab)
Definition
pegylated fab fragment (prolonged circulation, protected against enzematic degradation, slower renal filtration and improved stability) warning; infection risk, cancer onset, get immunizations early and avoid live vaccines
Term
golimumab (simponi)
Definition
human-derived mAB against TNF alpha, SQ, same contraindications, seek medical attention if there is any sign of infection
Term
anakinra
Definition
IL-1 receptor inhibitor, blocks inflammatory signaling (monocyte/macrophage activation, fibroblast proliferation, and chondrocyte activation)
Term
tocilizumab
Definition
recombinant humanized mAB binds IL6 receptor, increased risk of serious infections
Term
abatacept
Definition
costimulation modulator the blocks signal 2 of T cell activation, weight based dosing
Term
rituximab
Definition
anti-CD20 specific for B cells mAB, B cell apoptosis, infusion rxns and pancytopenia
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