Shared Flashcard Set

Details

Rheumatoid Arthritis
Ch 72: Rx Therapy of RA
13
Nursing
Undergraduate 3
12/12/2011

Additional Nursing Flashcards

 


 

Cards

Term

Rheumatoid Arthritis

definition

Definition

-autoimmune inflammaroty disorder 

joint inflammation---> destruction 

---treatment goal is to prevent further distruction

Term
classes of AntiArthritic Rx
Definition
  1. NSAID's
  2. DMARD's (disease modifying antirheumatic drugs)
  3. Glucocorticoids/ corticosteroids (local injection)
Term

AntiArthritic Rx

DMARD's

first choice agents

Definition
  1. methotrexate (DOC)
  2. hydrochloroquine
  3. sulfasalazine
Term

AntiArthritic Rx

DMARDs

biologic agents

Definition

etanercept

infliximab

adalimumab

golimumab

leflunomide

anakinra

abatacept

rituximab

tocilizumab

Term

AntiArthritic Rx

methotrexate

overview

Definition

most RAPID acting DMARD (3-6 wks)

weekly oral adminictration

ADRs

-hepatic fibrosis (alchy)

-bone marrow suppression

-GI ulceration

-pneumonitis

Term

 

AntiArthritic Rx

 

hydrochloroquine

Definition

moderate acting: 3-6 months

retinal damage

ORAL

Term

 

AntiArthritic Rx

sulfasalazine

 

Definition

moderately rapid acting 

(methotrex>sulf>hydro)

used for ulcerative colitis

-dec effectiveness for RA

Term

 

AntiArthritic Rx

Etanercept

overview

 

Definition

inactivation of TNF (tumor necrosis factor)

-involved with inflammation cascade

indicated for moderate to severe RA

SUB Q injection

ADR's

POSSIBLE SERIOUS INFECTION

Term

 

AntiArthritic Rx

infliximab 

and 

adalimumab

 

Definition

similar action to etanercept (TNF blocker)

also possible risk of infection

--inflix: given IV

--adalim: injection

Term

 

AntiArthritic Rx

Leflunomide

 

 

Definition

non biologic DMARD

-decreases t lymphocyte proliferation

ORALLLLL

ADRs

same (SERIOUS infection)

Term

 

AntiArthritic Rx

Anakinra

 

Definition

blocks interlukin-1 (IL-1) which is involved in inflammation

same ADRs

Term

 

AntiArthritic Rx

other DMARDs

 

 

Definition

golimumab (anti TNF)

abatacept (t cell inhibitor)

rituximub (tcell inhibitor and orig for lymphoma)

Term

 

AntiArthritic Rx

tocilizumab

 

Definition

newest anti RA Rx

interlukin 6 inhibitor

same risk for infection

Supporting users have an ad free experience!