Term
| Which cells do MHC class I interact with? |
|
Definition
| MHC class I acts a ligand to cytotoxic T cells via their TCR |
|
|
Term
| Name the receptors (3) on the Natural Killer Cell and what they bind to |
|
Definition
NKG2D on NK binds with MIC ligand on pathogen (infection)
Fc(gamma)R on NK binds with IgG coating pathogen in adaptive immunity
Inhibitory receptor on NK binds to MHC class I presenting self receptor (no infection) |
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|
Term
| What do natural killer cells do? |
|
Definition
| Kill virally infected cells |
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Term
| Newborns contain which isotype? |
|
Definition
| IgG because it can cross the placenta |
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Term
| Beginning stage of Primary Immune response |
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Definition
|
|
Term
| late stage of secondary immune response |
|
Definition
|
|
Term
| beginning stage of secondary immune response |
|
Definition
| IgG, B cells go into memory cells |
|
|
Term
| on which cells does affinity maturation occur? |
|
Definition
| activated B cells (Ag primed) |
|
|
Term
| When do B cells met dc cells? |
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Definition
|
|
Term
| affinity maturation of B cells |
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Definition
| Dc cells present ag via MHC class II to B cells, if they hold tight they survive and then activated B cells can go present ag to T helper cells via MHC class II and then T helper cells secerete IL-4 and IL-5 |
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| is Th-2 involved in ADCC? |
|
Definition
|
|
Term
| which cells produce immunoglobulins? |
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Definition
|
|
Term
| Another word for T cell activation? |
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Definition
|
|
Term
| What is the cytokine involved in T cell activation? |
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Definition
|
|
Term
| on which T cells do they first and secoond signals occur? |
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Definition
|
|
Term
|
Definition
| when there is no 2nd signal |
|
|
Term
| What does anergy function in? |
|
Definition
|
|
Term
| How does a virally infected dendritic cell present antigen? |
|
Definition
| on MHC I to cytotoxic t cells |
|
|
Term
| how does a virally infected target cell present antigen? |
|
Definition
| on MHC I to cytotoxic T cells |
|
|
Term
| Is 2nd signal required for target cell and effector cell interaction? |
|
Definition
|
|
Term
|
Definition
| CD40R and CD40L on T cells |
|
|
Term
| When does B cell present CD40L? |
|
Definition
| in affinity maturation with dendritic cells |
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|
Term
| When T cell presents CD40L and dendritic cell presents CD40... |
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Definition
|
|
Term
| Do Th-2 always need to activate B cells? |
|
Definition
| No, B cells can be activated via T independent antigen |
|
|
Term
| What type of immunglobulin coats super anitgens? |
|
Definition
|
|
Term
| Which molecule has the highest immunogenicity? |
|
Definition
|
|
Term
| Where does isotype switching occur? |
|
Definition
| germinal centers in lymph nodes |
|
|
Term
| Which immunoglobulin does isotype switching start with? |
|
Definition
|
|
Term
| On which cells is CD4 a co receptor? |
|
Definition
| T helper cells AND T regulatory cells |
|
|
Term
| What do T regulatory cells do? |
|
Definition
| supress immune response and peripheral tolerance |
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|
Term
|
Definition
| marker in human stem cells |
|
|
Term
| Which 2 cells are responsible for phagocytosis? |
|
Definition
| macrophages and neutrophils |
|
|
Term
| Are chemokines important for phagocytosis? |
|
Definition
| Yes, they call neutrophils to the sceane |
|
|
Term
|
Definition
| stops somatic recombination in alleles |
|
|
Term
| on which cells does allelic exclusion occur? |
|
Definition
|
|
Term
| Which parts of the immunoglobulin are regulated by allelic exclusion? |
|
Definition
|
|
Term
| Which parts of the TCR are regulated by allelic exclusion? |
|
Definition
|
|
Term
| How is the hypervariable region formed? |
|
Definition
|
|
Term
| Allelic exclusion is important for? |
|
Definition
| hypervariable specificity |
|
|
Term
| is inflammatory response always good for the general health condition? |
|
Definition
|
|
Term
| T cell activation leads to... |
|
Definition
|
|
Term
| when pathogen is defeated what is expressed on the T cells? |
|
Definition
|
|
Term
| when a T cell attacks a virally infected cell does it need a secondary signal? |
|
Definition
|
|
Term
| when a dendritic cell presents a self antigen is there a second signal? |
|
Definition
|
|
Term
| where is primary tolerance mediated? |
|
Definition
|
|
Term
| how is primary tolernace mediated? |
|
Definition
|
|
Term
| how is peripheral tolerance mediated? |
|
Definition
| anergy and t regulatory cells (IL-10) |
|
|
Term
| Does isotype switching add diversity to B cells? |
|
Definition
|
|
Term
|
Definition
| any individual difference |
|
|
Term
|
Definition
| physical structure differences |
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|
Term
|
Definition
|
|
Term
| T independent B cell activation |
|
Definition
| B cells cross link strong to antigen |
|
|
Term
| In T dependent B cell activation B cells normally need |
|
Definition
| Th-2 Cells, IL-4 and IL-5 |
|
|
Term
| B cells interact with pathogens by.. |
|
Definition
| binding their Fc receptor to the immunglobulin on the surface of the cell |
|
|
Term
| B cells interact with T helper cells by... |
|
Definition
| presenting the antigen via MHC II |
|
|
Term
| T cells respond to B cells by... |
|
Definition
| producing IL-4 and IL-5 and clonally expanding |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| does Th-2 contribute to ADCC? |
|
Definition
|
|
Term
| Does innnate immuniy change in second response? |
|
Definition
|
|
Term
| How does adaptive immunity function in seoncdary response |
|
Definition
| preformed antibody and memory cells |
|
|
Term
| Does ADCC happen at the beginning of primary immune response? |
|
Definition
| no because no antibodies yet |
|
|
Term
| What is the first antibody to show up? |
|
Definition
|
|
Term
|
Definition
| coat/opsonize for phagocytosis and neutralize the bacteria |
|
|
Term
| are antibodies effective when virus is extra cellular? |
|
Definition
|
|
Term
| How are antibodies effective on extra cellular virus? |
|
Definition
| block active structure and neutralize structure |
|
|
Term
| PLasma cells are in which lineage? |
|
Definition
|
|
Term
| How many binding sites does IgM have? |
|
Definition
|
|
Term
| isotype in seondary immune response? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Chemotoxins in innate immunity? |
|
Definition
|
|
Term
| which receptors do MHC interact with? |
|
Definition
|
|
Term
| are MHC's ligands or receptors? |
|
Definition
|
|
Term
| What was Jenner famous for? |
|
Definition
|
|
Term
| Immunoglobulins (3 things) |
|
Definition
expresses on cell surfaces
receptor on B cells and T cells
secreted by plasma cells |
|
|
Term
| how are TCR similar to antibodies on B cells? (2) |
|
Definition
they both posesse structure domain known as immunoglobulin
they have heavy and light chains (beta and alpha) |
|
|
Term
| When hematopoietic stem cells enter the thymus what are the called? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Who expresses receptors for CCR7 |
|
Definition
| T cells, B cells, and dendritic cells |
|
|
Term
|
Definition
| directs cells into secondary lymph tissue |
|
|
Term
| What are the two isotypes for light chain in antibodies? |
|
Definition
|
|
Term
| what is the ratio of kappa: lambda? |
|
Definition
|
|
Term
| Too much kappa in a person could mean? |
|
Definition
| malignant B cells because leukemia changes the ratios |
|
|
Term
|
Definition
|
|
Term
| which cell does HIV infect? |
|
Definition
|
|
Term
| what fraction of T cells are CD8? |
|
Definition
|
|
Term
| what fraction of T cells are CD4? |
|
Definition
|
|
Term
| can a physical condition change antigen strength? |
|
Definition
|
|
Term
| can antigen-antibody specificity change? |
|
Definition
|
|
Term
| bone marrow transplantation |
|
Definition
| enrich stem cells into peripheral blood in order to increase the peripheral blood in circulation |
|
|
Term
| What cytokines do macrophages produce? (6) |
|
Definition
| IL-6, IL-1, CXCL8, GM-CSF, INF, TNF |
|
|
Term
|
Definition
| signaling receptor, stimulates acute phase protein production in liver |
|
|
Term
|
Definition
|
|
Term
|
Definition
| brings neutraphils to infection site |
|
|
Term
|
Definition
| increases production of stem cells in bone marrow |
|
|
Term
|
Definition
| increases amount of natural killer cells and cytotoxic t cells and interferes with viral replication |
|
|
Term
|
Definition
| increases inflammatory responses |
|
|
Term
|
Definition
| tolerance is lost to self antigen |
|
|
Term
|
Definition
| soluble or on cell surface |
|
|
Term
|
Definition
| receives a signal, could be used as a marker |
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|
