Term
| What pathway is activated by antigen-antibody complexes? |
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Definition
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Term
| What pathway is activated by MBL? |
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Definition
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Term
| What pathway involves the direct binding of C3b to microbial surfaces? |
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Definition
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Term
| Where are most circulating soluble complement proteins synthesized? |
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Definition
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Term
| Where do the three complement pathways converge? |
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Definition
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Term
| Which complement subunits induce inflammation by recruiting inflammatory cells to the site of activation (chemotaxis)? |
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Definition
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Term
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Definition
| It creates binding sites for Factor B. |
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Term
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Definition
| It exposes binding sites for Factor D. |
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Term
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Definition
| It cleaves Factor B into Ba and Bb subunits. |
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Term
| How long after infection does the alternative pathway work? |
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Definition
| 0-4 hours after infection. |
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Term
| List two acute-phase proteins that can activate C3. |
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Definition
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Term
| What causes the release of acute phase proteins? |
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Definition
| Inflammatory cytokines such as IL-6. |
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Term
| When do CRP and MBL activation of C3 occur? |
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Definition
| 4-96 hours after infection. |
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Term
| What is the function of MASP-1 and MASP-2? |
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Definition
| Cleave C2 and C4 upon binding of MBL to microbial surfaces. |
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Term
| What is the function of C2b and C4a? |
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Definition
| They are soluble proteins that have inflammatory properties. |
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Term
| What convertase is formed in the lectin pathway? |
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Definition
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Term
| What is another name for C4bC2a? |
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Definition
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Term
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Definition
| It binds to antigen-antibody complexes. |
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Term
| Which component of C1 binds to the Fc region of antibodies? |
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Definition
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Term
| Which components of C1 are proteases? |
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Definition
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Term
| Which antibodies activate complement? |
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Definition
| IgG and IgM (more strongly than IgG). |
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Term
| What does the active form of C1s do? |
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Definition
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Term
| How is a C5 convertase generated? |
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Definition
| Binding of additional C3b molecules to a C3 convertase. |
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Term
| What molecules initiates assembly of the MAC? |
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Definition
|
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Term
| What does C1 inhibitor do? |
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Definition
| It inhibits the protease activity of C1. |
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Term
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Definition
| Removes Bb from the C3bBb complex and recruits Factor I. |
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Term
|
Definition
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Term
|
Definition
| Binds do C3b and displaces Bb. |
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Term
|
Definition
| Binds to C3b and recruits Factor I to cleave C3b. |
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Term
| What does CD59 (protectin) do? |
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Definition
| It inhibits the recruitment of C9. |
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Term
|
Definition
| It enhances activation of the alternative pathway by attracting C3b and stabilizing C3bBb. |
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