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Reverse Cholesterol Transport
Medical School Biochemistry
13
Biochemistry
Graduate
10/26/2011

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Cards

Term
What is the function of Apo A1?
Definition
Apo binds to LCAT
Term
What is the function of LCAT?
Definition
LCAT is an enzyme that makes a cholesterol into a cholesterol ester
Term
What is the function of LCAT?
Definition
LCAT is an enzyme that makes a cholesterol into a cholesterol ester
Term
How does an HDL form?
Definition
A1 associates with a cholesterol rich phospholipid
Term
What forces form a nascent HDL?
Definition
Hydrophobic forces, no energy is required
Term
What is CETP?
Definition
Cholesteryl Ester transfer protein. It is a protein that exchanges Cholesterol esters, triglycerides, and apoproteins between remnants and HDLs
Term
What apoproteins can cross from remnants to HDL in the present of CETP?
Definition
A2, E, C2
Term
What apoproteins can transfer from HDL's to remnants in the presence of CETP?
Definition
A1
Term
Why can you not cut out all the fat in a diet when trying to promote good cardiovascular health?
Definition
Fat is important in the synthesis of A1 and E, crucial apoproteins for the creation of HDL's
Term
What is the therapeutic effect of bile salt resins?
Definition
Bile salt resins cause bile salt malabsorption and force the liver to synthethize more bile salts from resin
Term
What is the therapeutic effect of statins?
Definition
decrease the activity of Cholesterol synthesis and upregulate the amount of LDL receptors
Term
What is the therapeutic effect of statins?
Definition
decrease the activity of Cholesterol synthesis and upregulate the amount of LDL receptors
Term
What is the therapeutic effect of drugs like Zetia?
Definition
blocks the absorption of cholesterol by the intestine
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