Term
| Where does HIV go in early infection? |
|
Definition
| gp120 binds to CD4 cells and CCR5 macrophage and dendritic cells |
|
|
Term
| where does HIV bind in late infection? |
|
Definition
| CD4 and CXCR on helper T cells via gp41 fusion |
|
|
Term
| in the HIV life cycle, genomic RNA and mRNA are transcribed from |
|
Definition
|
|
Term
| What is the importance of the protease? |
|
Definition
| it cleaves the protein to release RT allowing the infectious virus to form. |
|
|
Term
| what is the function of Tat? |
|
Definition
trans activator of transcription
essential in replication |
|
|
Term
|
Definition
| regulates mRNA synthesis and transport |
|
|
Term
|
Definition
| reduces CD4 and HLA class 1 expression |
|
|
Term
|
Definition
| viral assembly and maturation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| nuclear transport of viral cDNA |
|
|
Term
| this is a correlate of high virus load in the blood. |
|
Definition
|
|
Term
| this lab test detects viral RNA in the blood |
|
Definition
|
|
Term
|
Definition
ELISA
confirmed by Western Blot |
|
|
Term
| where does HIV maintain a persistent infection |
|
Definition
| macrophages and CD4 T cells |
|
|
Term
| Mutation in this gene leads to shift in tropism toward CD4 T cell infection |
|
Definition
|
|
Term
| What are the initial symptoms of AIDS |
|
Definition
| mono, fever, and widespread lymphadenopathy |
|
|
Term
| What does the treatment HAART consist of |
|
Definition
| combination of RT inhibitors w/protease inhibitors |
|
|
Term
| non-nucleoside analog RT inhibitors |
|
Definition
|
|
Term
| what is HTLV-1 associated w/ |
|
Definition
adult T cell lymphocytic leukemia
tropical spastic paraperesis |
|
|
Term
|
Definition
| viral tax proteins causing activation of IL-2 growth factors |
|
|
Term
| How is HTLV-1 transmitted? |
|
Definition
sexual contact
breast milk |
|
|
