Term
Influenza Type A Virus:
Genomic structure?
Spikes?
How are type B and C different? |
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Definition
8 segments ss (-) RNA
H and N (H1, H2, H3 and N1, N2)
Type B: also has 8 segments
Type C: has 7 segments
Type A undergoes greatest antigenic drift |
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Term
Influenza Virus:
What spike mediates adsorption, envelope fusion and viral release?
Where does the virus uncoat?
Where does the virus replicate? |
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Definition
Adsorption: H
Envelope fusion, viral release: N
Uncoats in cytoplasm
Only (-) RNA virus that replicates in the nucleus |
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Term
Influenza - Clinical Disease:
Incubation time?
Symptoms?
Where does it infect?
What are the possible complications? |
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Definition
Incubation: 1-2 days
Symptoms: myalgia, headache, chills, cough, fatigue
Infect upper respiratory tract
Complications: Rey's Guillain-Barre |
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Term
How do you diagnose influenza?
What is the treatment? |
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Definition
Diagnosis: Ab titer to H
Treatment: Amantadine, Rimantadine
or
Zanamivir and oseltamivir (neurominidase -) |
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Term
Parainfluenza:
How many serotypes? |
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Definition
| 4 - antigenic variations leading to different Abs |
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Term
Parainfluenza:
What is the genomic structure?
What spikes does the envelope contain? |
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Definition
Genomic structure: ss (-) RNA
Envelope: H, N, and F (fusion) |
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Term
Parainfluenza:
Where and how does the replication occur? |
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Definition
| In the cytoplasm like a (-) RNA virus |
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Term
Parainfluenza - Clinical picture:
Describe the clinical picture for the following:
Parainfluenza 1
Parainfluenza 2
Parainfluenza 3
Parainfluenza 4 |
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Definition
Parainfluenza 1: Major cause of acute croup, laryngotracheitis (larynx and trachea)
Parainfluenza 2: Croup
Parainfluenza 3: Severe bronchitis and/or pneumonia
Parainfluenze 4: Least common - mild upper respiratory tract illness |
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Term
Respiratory Syncitial Virus:
What spikes does the envelope contain?
What is the genomic structure? |
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Definition
Spikes: G, F
Genomic structure: ss (-) RNA, non-segmented |
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Term
Respiratory Syncitial Virus:
What diseases does it create? |
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Definition
| Single most important agent of bronchiolitis nad pneumonia. Starts in the upper respiratory tract and works its way down. |
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Term
| How is respiratory syncitial virus diagnosed? |
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Definition
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Term
Adenovirus?
Number of serotypes?
Structure?
Replication? |
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Definition
47
ds DNA, naked, icosahedral
Replicates in the nucleus |
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Term
| Describe the clinical disease? |
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Definition
Persists from days to years
Subclinical
Febrile childhood respiratory disease
Pharyngoconjuctival disease
Pertussis-like disease in children
Conjuctivis
Cystitis
Gastroenteritis |
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