Term
| What increases Bronchoconstriction (and the three drugs to block these) |
|
Definition
ACh (Ipratropium)
Adenosine (Theophyline)
Leukotrienes (Zileuton or Zafirlukast |
|
|
Term
| H1 Blockers 1st generation (6) |
|
Definition
Diphenhydramine
Dimonhydramine
Chlorpheniramine
Promethazine
Hydroxyzine- sedative
Meclizine- motion sickness |
|
|
Term
| H1 blocker 1st generation clinical uses |
|
Definition
N/V in pregnancy
Allergy
Motion Sickness
Sleep Aid |
|
|
Term
| H1 blocker 1st generation side effects |
|
Definition
Sedation
antimuscarinic
anti alpha adrenergic |
|
|
Term
| H1 Blocker 2nd generations and major use |
|
Definition
Used in allergies
Loratidine
Foxofenadine
Desloratadine
Cetirizine |
|
|
Term
| Short term B2 agonist used to relax bronchus smooth muscle |
|
Definition
| Albuterol (also terbutaline, metaproterol) |
|
|
Term
|
Definition
|
|
Term
| What is a methyxanthine used for asthma |
|
Definition
|
|
Term
|
Definition
| Bronchodilator by inhibiting phosphodiesterase, and decreasing hydrolysis of cAMP. Also blocks adenosine |
|
|
Term
| 2 Side effects of theophyllin |
|
Definition
Cardiotoxic (narrow theuraputic index)
Neurotoxic
Metabolized by P-450 |
|
|
Term
| Is Ipatropium and competitive or non competitive blocker of muscarinic receptors. |
|
Definition
|
|
Term
| What has less side effects: B-agonists or Muscarinic antagonist |
|
Definition
| Muscarinic antagonist because antagonist have 0 efficacy. Ipatropium would be safer in CV disorders along with bronchospasms caused by B-agonists |
|
|
Term
| Cromolyn (nedocromil) MOA |
|
Definition
| Prevents release of mediators from mast cells, decreases Histamine, PAF, LTC4 from inflammatory cells |
|
|
Term
| Is Cromolyn used for prophylaxis or acute exacerbation |
|
Definition
|
|
Term
| MOA of Corticosteroid in Asthma |
|
Definition
| Inhibits the synthesis of cytokines. Inactivates NF-kB, the transcription factor that induces the production of TNF-alpha among other inflammatory agents |
|
|
Term
| What is the 1st line treatment for chronic asthma |
|
Definition
| Corticosteroids (Beclomethasone) |
|
|
Term
|
Definition
| 5-lox pathway inhibitors, blocks conversion of AA to leukotriene. |
|
|
Term
| Zafirlukast and Montelukast MOA |
|
Definition
| Blocks Leukotriene receptors. Especially good for aspirin induced asthma |
|
|
Term
| Usage difference between Zileuton and Zafirlukast |
|
Definition
Zileuton-acute
Zafirlukast-chronic |
|
|
Term
| Guaifenesin and N-acetylcysteine are used for what |
|
Definition
Expectorants:
Guaifenesin- removes excess sputum, does not suppress cough reflex
N-acetylcysteine- can loosen mucous plugs in CF patients |
|
|
Term
|
Definition
Competitively antagonizes endothelin 1 receptor, decreasing pulmonary vascular resistance
Pulmonary HTN |
|
|
Term
|
Definition
| CI in Pregnancy and can cause Vasodilation |
|
|
Term
| Antitussive (antagonizes NMDA) synthetic codeine analog |
|
Definition
|
|
Term
| Sympathomimetic alpha agonist non prescription nasal decongestants |
|
Definition
| Pseudoephedrine and Phenylephrine |
|
|
Term
|
Definition
Opens Eustachian Tubes
Nasal Congestion
Hyperemia
edema |
|
|
Term
|
Definition
|
|
