Shared Flashcard Set

Details

Respiratory Pathology
Upper & Lower Respiratory Tract Neoplasia
48
Medical
Professional
02/27/2008

Additional Medical Flashcards

 


 

Cards

Term
Major type of laryngeal carcinoma
Definition
squamous cell
Term

Primary cause of laryngeal carcinoma

Secondary cause of laryngeal carcinoma

Definition

Smoking

 

Ethanol

Term
Laryngeal Carcinoma Type with the highest 5 year survival rate
Definition
Glottic
Term
Lung cancer associated with p53 mutation
Definition
squamous cell carcinoma
Term
Lung cancer associated with inactivation of RB gene
Definition
small cell lung carcinoma
Term
Lung cancer assoicated with KRAS mutation
Definition
Adenocarcinoma
Term

Which lung cancer is associated with intracellular bridges?

With glandular differentiation?

Definition

squamous cell carcinoma

 

adenocarcinoma

Term
What is the most common type of lung cancer?
Definition
Metastatic
Term
What is the most common primary lung cancer type?
Definition
adenocarcinoma
Term

Location of:

Small Cell Carcinoma

Squamous Cell

Adenocarcinoma

Large cell

Definition

Small Cell and Squamous: Central

 

Adeno and Large: Peripheral

Term
Neurosecretory granules are characteristic of which lung cancer type?
Definition
small cell carcinoma
Term
Which lung cancer type has the highest rate of metastasis?
Definition
small cell carcinoma
Term

Which lung cancer has characteristic keratinization and intercellular bridges (desmosomes and tonofilaments)?

Definition
squamous cell carcinoma
Term
Which type needs a mucin stain for diagnosis?
Definition
Adenocarcinoma
Term

Which lung cancer has following characteristics:

tumor cells grow on existing alveoli

preserved lung architecture

absence of stromal invasion

Definition
Bronchioloalveolar carcinoma
Term
What are the gross and micro feautures of bronchioloalveolar carcinoma?
Definition

Gross: nodules or foci of consolidation

 

Micro: mucinous or nonmucinous

Term
What are the staging features for nonsmall cell carcinoma?
Definition

primary tumor characteristics

 

regional lymph node metastasis

 

distant metastasis

Term
What is the staging for small cell carcinoma?
Definition

Limited: confined to 1 hemithorax +/- mediastinal LNs, ipsilateral supraclavicular LNs, ipsilateral pleural effusion

 

Extensive: any growth more than limited

Term

a disease or syndrome that is the consequence of cancer in the body but not due to the local presence of these cells

Definition
paraneoplastic syndrome
Term
can cause increased ACTH (Cushings syndrome)
Definition
small cell
Term
can cause inappropriate ADH secretion
Definition

small cell

Term
May cause hypercalcemia due parathyroid like hormone
Definition
squamous cell carcinoma
Term

marker for neuroendocrine tumor?

 

what cancer type would it be associated with

Definition

synaptophysin

 

small cell carcinoma

Term
TTF1 is normally positive in what type of cancer?
Definition
Primary cancer
Term
What is a marker for metastatic cancer?
Definition
cytokeratin
Term
Which cancer type may produce symptoms of intermittant diarrhea, flushing, and cyanosis?
Definition
carcinoid tumor
Term
Which type of cancer has a trabecular growth pattern and nesting with pseudoglands?
Definition
carcinoid tumor
Term
What is the most common benign pulmonary tumor?
Definition
hamartoma
Term
What is a malignant neoplasm arising from pleural cells?
Definition
malignant mesothelioma
Term
Significant risk factor for malignant mesothelioma
Definition
asbestos
Term

Stain is cytokeratin positive:

 

Is it a sarcomatoid malignant mesothelioma?

Sarcoma?

Epitheliod malignant mesothelioma?

Adenocarcinoma?

Definition
sarcomatoid malignant mesothelioma
Term

Which has neutral mucin:

 

malignant mesothelioma or adenocarcinoma?

Definition
adenocarcinoma
Term

Which has acid mucin with alcian blue stain:

 

malignant mesothelioma or adenocarcinoma?

Definition
malignant mesothelioma
Term

Which is TTF1 positive:

 

malignant mesothelioma or adenocarcinoma?

Definition
adenocarcinoma
Term

Which is calretinin positive (nuclear and cytoplasmic):

 

malignant mesothelioma or adenocarcinoma?

Definition
malignant mesothelioma
Term
Which cancer type is common in nonsmokers and young patients?
Definition
Adenocarcinoma
Term
Which type of cancer is commonly associated with hilar adenopathy?
Definition
Large cell
Term
Which cancer type is hemoptysis and post obstructive pneumonia most common?
Definition
squamous cell
Term
Most commonly associated with metastasis?
Definition
small cell carcinoma
Term
Patient with this cancer type may present with lethargy, confusion, and seizures (due to hyponatremia)
Definition
small cell carcinoma
Term
Pt may present with skeletal connective tissue syndromes (clubbing)
Definition
non small cell
Term

Hypertrophic pulmonary osteoarthropathy associated with what type?

(clubbing, periosteal bone inflammation causing pain, swelling, tenderness over affected bones)

Definition
adenocarcinoma
Term
mainstay of palliation for patients with small cell carcinoma
Definition
chemo
Term
requirements for surgical resection
Definition

tumor limited to one side of chest, located at least 2cm from carina, no metastasis!

 

patient can tolerate ventilator

Term
used in patients with small cell carcinoma with brain metastasis
Definition
radiation therapy
Term

True or False:

50% of solitary pulmonary nodules (coin lesions) are malignant.

Definition
True
Term

Factors supporting benign lesion:

Size

Age

History

Etc.

Definition

Size < 1cm diameter

Young (<35 yo)

No hx of smoking

high incidence of alt explanation (histoplasmosis, Tb)

calcification pattern on CXR

No change in lesion over 2yrs

Term
What is the best management for a patient with a solitary pulmonary nodule that does not meat the factors for benign lesion?
Definition
surgical resection
Supporting users have an ad free experience!