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reproductive physiology
R-GU
46
Medical
Graduate
09/28/2010

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Term
what is the purpose of reproduction?
Definition
continuation of the species, genetic variability, expression of dominant/beneficial traits, and suppression of harmful/recessive traits
Term
what are the advantages to sexual reproduction?
Definition
greater genetic variability, repression of recessive traits, better adaptability and co-expression of traits
Term
what is dyspareunia? what can it be due to?
Definition
pain w/intercourse, which can be due to lack of lubrication, endocrine problems, lack of appropriate stimulation, etc
Term
can ibuprofen affect the closing of the patent ductus arteriosus in an fetus/infant?
Definition
yes
Term
what are physiologic factors which can affect spermatogenesis?
Definition
blood flow to the testis, temperature of the testis, teratogenic medications, and the male sexual act
Term
what are possible things which could go wrong with individual sperm?
Definition
defective genetic material, energy production, tail function (kartagener’s), or low total number of sperm
Term
what are germ cells? what other cells help them?
Definition
cells destined to become gametes. they first divided mitotically, then meiotically. sustentacular cells such as sertoli and leydig cells support this process.
Term
what three things need to be considered which may be affected by male sex hormones?
Definition
accessory sexual organs, cellular metabolism, and growth
Term
what is one purpose of hair and rugae on the male scrotum?
Definition
to increase surface area for secretions and thus increase the intensity of smell
Term
what muscle changes how far the testes descend? why is this necessary?
Definition
the cremaster, which is necessary b/c spermatogenesis occurs at 1 degree temp lower than the rest of the body
Term
how can mumps lead to infertility?
Definition
inflammation in the testis can cause swelling in the seminiferous tubules (orchitis) which ultimately may destroy the germ cells/gametes
Term
what could pain in a testis represent?
Definition
torision, orchitis, or inflammatory process
Term
what is the purpose of smooth muscle in the vas deferens?
Definition
to move sperm out of the testis
Term
if the prostate becomes sclerotic/hard, how can this affect function?
Definition
flow of urine/ejaculate will be impeded
Term
what is infection of the glans?
Definition
balanitis
Term
what can lack of circumcision increase risk of?
Definition
paraphimosis, fungal infection in DM pt, any kind of infection in immunocompromised
Term
what does the acrosome of a sperm cell contain?
Definition
proteolytic enzymes
Term
what is found in the body of a sperm cell?
Definition
mitochondria
Term
how can mucolytics decrease the function of birth control?
Definition
anti-tussives may decrease the efficacy of mucus increasing birth control
Term
how could a blow to the nose create an endocrine problem?
Definition
FSH is created by the pituitary at the base of the brain behind the sphenoid bone.
Term
**what does FSH do?**
Definition
FSH is responsible for sertoli cell stimulation in males and follicle enlargement in females.
Term
**what does LH (luteinizing hormone) do?**
Definition
stimulates leydig cells for testosterone secretion in males and helps regulate body temp/tissue formation in females
Term
what hormone may be deficient in pts not reaching adequate developmental milestones?
Definition
growth hormone
Term
**what is testosterone necessary for in females?**
Definition
testosterone is essential for division of testicular germinal cells - which are secreted by the leydig cells
Term
**where is estrogen produced in females?**
Definition
the sertoli cells (estrogen is formed from testosterone)
Term
when are testosterone levels peaked in males?
Definition
between late teens and early 30s
Term
how many sperm are produced daily in a normal male?
Definition
120 million
Term
what speed do sperm move at?
Definition
1-4 mm/min
Term
how long do sperm live in the vas deferens? in the female genital tract?
Definition
vas deferens: ~1 month. female genital tract: 1-2 days
Term
**what do the seminal vesicles add to semen?**
Definition
fructose, citric acid (fuel), prostaglandins , fibrinogen
Term
**what does the prostate gland add to semen?**
Definition
Ca++ (important for flagellar motility), citrate, clotting enzymes, fibrinolysin (break into ovum), and alkaline secretions (acid phosphatase - important b/c female genital tract has a lower pH)
Term
where does the prostate gland sit?
Definition
under the bladder
Term
what can BPH cause?
Definition
increased tension - harder to pee/ejaculate. pts complain of back pain and fatigue (lack of sleep b/c getting up to pee).
Term
what percentages of contribution do the various male sex glands make up in semen?
Definition
seminal vesicle: 60%, prostate: 30%, vas deferens: 10%
Term
can a male have a normal sperm count and still be infertile?
Definition
yes
Term
what is the necessary balance of temperature for the testicles?
Definition
not too hot, but not too cold - b/c cremaster reflex can be stimulated
Term
what is the acrosomal reaction?
Definition
sperm gets into the fallopian tube, penetrates the zona pellucida (hydrolytic reaction) and *halt penetration of other sperm (changes electromagnetic field).
Term
what are the main male fertility factors?
Definition
intact anatomy, sperm #, sperm motility, and testicular swelling
Term
what factors are important for a successful male sexual act?
Definition
psychological (stress, disease, sleep problems, medication), stimulation of the glans (produces feedback from the spinal cord to the limbic system to enhance blood flow to the corpus cavernosom and spongiosum - need good nerve/blood flow), secretion/lubrication (reduce friction, can be issue in menopausal women), penile erection (parasympathetic, need good blood/nerve flow), and emission/ejaculation (symapathetic, can be affected by medication)
Term
what are the male sex hormones (androgens)?
Definition
testosterone, dihydrotestosterone, androstenedione
Term
what are the male sex hormones (androgens)?
Definition
testosterone, dihydrotestosterone, androstenedione
Term
what do the leydig cells do?
Definition
maintain the appropriate level of testosterone for spermatogenesis (w/o these: germinal cells do not appropriately multiply, appropriate meiosis and mitosis will not occur and spermatids will not form)
Term
what is important to check in newborn males?
Definition
testicular descent (requires testosterone)
Term
what are the effects of testosterone?
Definition
testicular descent, hair distribution, baldness (thought to be related to incremental testosterone buildup - inhibits protein synthesis), voice (vocal cords thicken), acne (clogged pores+bacteria), scrotal changes (abdominal pain can be referred if problems w/this), bone/muscular growth ("protect the family"), basal metabolism (revs up for growth), increased RBC mass (increased O2 delivery for growing tissues - however possible risk of polycythemia, heart has to work harder), and increased Na+/H2O retention (need more extracellular fluid to accommodate increased growth - can cause increased body weight and increase irritability w/nerve pressure)
Term
what is increased by sexual reproduction?
Definition
genetic variability
Term
what happens during spermatogenesis?
Definition
a big germ cell goes from a diploid to haploid and produces spermatids that have an acrosome, body, band of mitochondria and flagellum
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