Term
Fibroadenoma-like tumor with overgrowth of fibrous component
characteristic leaf like projections seen on biopsy |
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Definition
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Term
Well circumscribed mobile marble-like mass
Premenopausal woman |
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Definition
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Term
| Most common benign neoplasm of the breast |
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Definition
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Term
| Fibrovascular fingerlike projection lined by epithelial and myoepithelial cells |
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Definition
Intraductal papilloma
Benign |
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Term
Benign breast tumor that produces bloody discharge
Finger-like projections with epithelium and myoepithelium |
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Definition
Intraductal papilloma
(Benign)
(papillomas usually bleed) |
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Term
Vague irregularity (lumpy breast) in upper outer quadrant
Cysts have a blue-dome appearance on gross exam
Premenopausal breast |
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Definition
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Term
Benign, but some associations are liked with invasive carcinoma in both breasts
1. fibrosis, cysts, aprocrine metaplasia
2. ductal hyperplasia and sclerosing adenosis (2x)
3. Atypical hyperplasia (5x) |
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Definition
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Term
Usually related to trauma
Abnormal calcification on mammography |
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Definition
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Term
Biopsy: shows fat necrosis with calcifications and giant cells
History may not be evident |
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Definition
| Fat necrosis - Trauma related |
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Term
Periaeriolar mass with green-brown nipple discharge
postmenopausal woman |
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Definition
Mammary duct ectasia
Dilation of the duct due to inflammation, and expulsion of inflammatory debris |
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Term
Subareolar mass with nipple retraction
Vitamin A deficiency
Female smoker |
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Definition
Periductal mastitis
Lack of vitamin A causes special epithelium in breast to undergo squamous transformation. inflammation and granulation tissue contract the tissue inward |
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Term
Warm erythematous breast with purulent nipple discharge.
Common cause of breast pain during breast feeding |
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Definition
Acute mastitis - caused by staph. aureus
Tx:
Drainage by continuing feeding
ABX - dicloxacillin |
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Term
| Treatment of acute mastitis caused by s. aureus |
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Definition
Drainage by continuing feeding
ABX - dicloxacillin |
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Term
| Risk factors for female breast cancer |
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Definition
Age
Early menarche/late menopause
Obesity
Atypical Hyperplasia
First degree relative with CA (mom, sister, daughter) |
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Term
| Malignant proliferation of cells in ducts with no invasion of basement membrane. |
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Definition
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Term
| Mammographic calcifications can be seen due to the central necrosis and dystrophic calcification in the center |
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Definition
Ductal carcinoma in situ
(Comedo type) |
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Term
| Most common INVASIVE carcinoma of the breast |
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Definition
| Invasive Ductal Carcinoma |
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Term
Malignant proliferation of well differentiated tubules that lack myoepithelial cells.
Relatively good prognosis |
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Definition
Invasive Ductal Carcinoma:
Tubular carcinoma |
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Term
Malignant proliferation with abundant extracellular mucin.
"tumor cells floating in a mucus pool" |
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Definition
Invasive Ductal Carcinoma:
Mucinous carcinoma
Good prognosis
Older women |
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Term
Malignant proliferation characterized by large, high grade cells growing in sheets associated with lymphocytes and plasma cells
Increased incidence in BRCA1 carriers |
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Definition
Invasive Ductal Carcinoma:
Medullary carcinoma |
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Term
Malignant proliferation with carcinoma in dermal lymphatics
Causing characteristic orange peel appearance |
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Definition
Invasive ductal carcinoma:
Inflammatory carcinoma |
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Term
Malignant proliferation of cells in lobules with no invasion of the basement membrane
characterized by dyscohesive cells lacking E-cadherin adhesion protein |
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Definition
Lobular carcinoma in situ
Tx: tamoxifen |
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Term
| Invasive carcinoma that characteristically grows in a single-file pattern |
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Definition
| Invasive lubular carcinoma |
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Term
| Malignant ductal carcinoma with caseous necrosis, paste-like secretions |
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Definition
Ductal carcinoma in situ:
Comedocarcinoma |
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Term
Associated with BRCA 2 mutations and Klinefelter syndrome
Subtype is invasive ductal carcinoma |
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Definition
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