Term
|
Definition
| inhibits ACE so dec ATII and prevents inactivation of bradykinin |
|
|
Term
|
Definition
|
|
Term
| prevent unfavorable heart remodeling as a result of chronic HTN |
|
Definition
|
|
Term
|
Definition
| cough, angioedema, proteinuria, tase changes, hypotension, teratogenic, rash, inc renin, low AII, hyperkalemia |
|
|
Term
| whey avoid ACEI in BL renal artery stenosis |
|
Definition
| significantly dec GFR by preventing constriction of efferent arterioles -> inc serum Cr |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| teratogen, hyperkalemia, inc CR; NO COUGH |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
mannitol
- MOA
- use
- toxicity |
|
Definition
- osmotic; inc tubular osmolarity
- sock, drug OD, inc intracranail/inraocular pressure
- pulmonary edema, dehydration, CI in anuria and CHF |
|
|
Term
acetazolamide
- MOA
- use
- toxiity |
|
Definition
- CA inhibitor
- glaucoma, urinary alkalinization, metabolic alkalosis, altitude sickness
- hyperchloremc metabolic acidosis, NH3 toxicity, sulfa allergy |
|
|
Term
furosemide
- MOA
- use
- toxicity |
|
Definition
- inhibits Na/K/2Cl; stimualtes PGE release; inhibited by NSAIDS
- CHF, cirrhosis, nephrotic, pulmonary edema, HTN, hypercalcemia
- Ototoxic, hypokalemia, dehydration, allergy, nephritis, gout |
|
|
Term
ethacrynic acid
- MOA
- use |
|
Definition
- same as furosemide but not sulfonamide
- diuresis with pt with sulfa allergy |
|
|
Term
|
Definition
- inhibits NaCl reabsorption, dec Ca excretion
- HTN, CHF, hypercalciuria, nephrogenic DI
- hyper glycemia, lipidemia, uriceia and calcemia; sulfa allergy |
|
|
Term
| K sparing aldosterone R antagonists |
|
Definition
| spironolactone and eplerenone |
|
|
Term
| K sparing block Na channels |
|
Definition
| triamterene and amiloride |
|
|
Term
K-sparing diuretics
- MOA
- use
- toxicity |
|
Definition
- aldosterone antag or inihibit Na in CCT
- hyperaldosteronism, K deplesion, CHF
- hyperkalemia, gynecomastia, antiandroen effects |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| diuretics leading to acidosis |
|
Definition
| CA inhibitors and K sparing |
|
|
Term
| diuretics causing alkalosis |
|
Definition
loops and thiazides
- volume contraction -> in ATII -> inc Na/H exchang ein PT -> inc HCO3; K loss -> K exiting all cells in exchange for H; H exchange for Na in CCT -> alkalosis |
|
|
Term
| effects on calcium with diuretics |
|
Definition
| inc with loops, dec with thiazides |
|
|
