Term
Palpable flank mass with flank pain, hematuria, hypertension, urinary infection
Presents in adulthood |
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Definition
Autosomal dominant polycystic kidney disease - ADPKD
Multiple, large, bilateral cysts that ultimately destroy the parenchma |
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Term
Palpable flank mass with flank pain, hematuria, hypertension, urinary infection. Can result in Potter's syndrome in utero, and hepatic fibrosis
Presents in childhood |
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Definition
| Autosomal recessive polycystic kidney disease (ARPKD) |
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Term
| Sequelae associated with polycystic kidneys |
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Definition
Polycystic liver disease
Berry Anneurism (SAH)
Mitral valve prolapse |
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Term
Most common renal malignancy
Associated with von Hippel-Lindau gene deletion on chromosome 3 |
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Definition
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Term
| Malignancy seen with polygonal clear cells. Presents with hematuria, palpable mass |
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Definition
Renal cell carcinoma
Associated with von Hippel Lindau gene deletion of chromosome 3 |
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Term
Malignancy associated with:
Polycythemia (via EPO)
Ectopic ACTH
PTHrP
Prolactin |
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Definition
|
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Term
| Most common renal malignancy in early childhood |
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Definition
Wilm's tumor
Associated with WAGR complex
(Wilms, aniridia, genital anomale, retardation)
Associated with WT1 tumor suppressor on chromosome 11 |
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Term
WAGR complex
Associated with WT1 tumor suppressor on chromosome 11 |
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Definition
Wilms tumor
Aniridia
Genitalurinary malformation
Retardation |
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Term
| Most common tumor of the urinary tract arising from the urothelial lining of renal pelvis, ureter, bladder or urethra |
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Definition
| Transitional cell carcinoma (urothelial CA) |
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Term
| Risk factors for transitional cell (urothelial) carcinoma |
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Definition
Smoking
Exposure to naphthylamine
Azo dyes
Long time cyclophosphamide or phenacetin use |
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Term
| Malignant proliferation of cells associated with chronic cystitis, chronic nephrolithiasis and schistosoma hematobium |
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Definition
| Squamous cell carcinoma of the bladder |
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Term
| Proliferation of glands from a urachal remnant, cystitis glandularis or extrophy of the bladder |
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Definition
| Adenocarcinoma of the kidney |
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Term
| Autosomal dominant disorder associated with hemangioblastoma of cerebellum and renal cell carcinoma |
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Definition
| von Hippel Lindau disease |
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Term
| Necrotic cells plugging tubules, obstructing tubules with "muddy brown casts" |
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Definition
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Term
| Causes of acute tubular necrosis |
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Definition
Obstruction/Crush injury (myoglobinuria)
Ischemia
Toxins (contrast agents)
Gentimicin
Sulfa drugs |
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Term
Acute renal failure with
Increase in BUN/Cr ratio in attempt to conserve volume |
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Definition
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Term
Acute renal failure
BUN absorption is impaired, will decrease the BUN/Cr ratio |
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Definition
| Intrarenal/intrinsic azotemia |
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Term
Acute renal failure with
Outlflow obstruction, will initially have normal BUN/Cr. After a long time will damage the tubular epithelium and get decreased BUN/Cr |
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Definition
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Term
WBC casts
CVA tenderness
Nausea
Vomiting |
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Definition
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Term
|
Definition
| Advanced renal disease (ESRD) |
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Term
| Acute interstitial renal inflammation due to drugs |
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Definition
| Acute interstitial nephritis |
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Term
| Drugs that cause Acute Interstitial nephritis |
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Definition
NSAIDS
Penicillin derivatives
Sulfonamides
Rifampin |
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